Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

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9780470631324: Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs.  The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

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Lays the groundwork for developing promising new drug candidates

Drawing on real-life examples, this book demonstrates the applications of transition metal catalysis in drug discovery and development, and its role in the efficient creation of both preclinical and clinical drug candidates as well as commercialized drugs. The authors pay particular attention to the challenges of transitioning reactions developed in academic labs into scalable industrial processes.

Applications of Transition Metal Catalysis in Drug Discovery and Development begins with a general overview of the use of transition metal catalysis in the pharmaceutical industry. Next, it covers:

  • Transition metal-catalyzed carbon–carbon cross-coupling reactions
  • Palladium- and copper-catalyzed carbon–heteroatom cross-coupling reactions
  • Asymmetric cross-coupling reactions and metathesis
  • Transition metal-catalyzed synthesis of five- and six-membered heterocycles
  • Oxidative catalysis and industrial asymmetric hydrogenation

Both the editors and authors are internationally recognized experts in drug discovery and development. All authors are scientists from such major pharmaceutical companies as Boehringer Ingelheim, GlaxoSmithKline, Merck, Amgen, and Novartis. Additionally, many of the authors have been responsible for developing the reactions and the drugs discussed in the book, providing readers with firsthand accounts of their discoveries.

This remarkable work serves as a guide, historical perspective, and practical compendium, offering pharmaceutical researchers and medicinal chemists a unique perspective on the applications of transition metal catalysis in drug discovery and development. Moreover, the book lays the groundwork for continued development of transition metal-catalyzed processes, setting the stage for new and promising drug candidates.

About the Author:

MATTHEW L. CRAWLEY, PhD, is the Director of the Community Physician Electronic Medical Records Program at Main Line Health. Previously, he has worked as a medicinal chemist at Pfizer and Wyeth Research. Dr. Crawley is an author of more than twenty publications, and his discoveries have resulted in several patents.

BARRY M. TROST, PhD, is Tamaki Professor of Humanities and Sciences in the Department of Chemistry at Stanford University. Dr. Trost has been elected a Fellow of the American Academy of Sciences and member of the National Academy of Sciences. He has served as chairman of the NIH Medicinal Chemistry Study Section, held over 120 university lectureships, and presented over 260 plenary lectures at national and international meetings.

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Book Description John Wiley and Sons Ltd, United States, 2012. Hardback. Book Condition: New. 1. Auflage. Language: English . Brand New Book. This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field. Bookseller Inventory # AAH9780470631324

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Book Description John Wiley and Sons Ltd, United States, 2012. Hardback. Book Condition: New. 1. Auflage. Language: English . Brand New Book. This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field. Bookseller Inventory # AAH9780470631324

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