Statistics in Human Genetics

Softcover

ISBN 10: 0470689285 ISBN 13: 9780470689288

Publisher: Wiley, 1997

Rigorous statistical analysis methods for human genetics application

Statistics in Human Genetics explores the statistical analysis methods that are critical to good science. Beginning with a brief review of genes, gene structure, variation, and terminology, the book moves into analysis of segregation, genetic linkage, allelic associations, and continuity for a wide range of conditions. From the classic Hardy-Weinberg equation to advanced modeling, algorithms and more, this book provides authoritative guidance toward methods, analysis, and applications for anyone performing quantitative analysis of human genetics.

From the Back Cover:

In human genetic research sophisticated statistical methods are increasingly being used to analyse results. Until now there has been no book to introduce and explain these methods. The methods are based on both biology and statistics and are likely to contribute to major scientific and medical advances in the next century. Topics include the estimation of allele frequencies, the testing for Hardy-Weinberg equilibrium, classical and complex segregation analysis, linkage analysis for Mendelian and complex diseases and quantitative traits, the detection of allelic associations, the estimation of heritability for multifactorial traits and path analysis. An understanding of elementary statistical concepts is assumed, but the objectives, principles and limitations of the methods are discussed in detail.

About the Author:

Pak Sham is at Institute of Psychiatry, London.