Protective Groups in Organic Synthesis

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9780471057642: Protective Groups in Organic Synthesis
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Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.

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From the Back Cover:

The Most Comprehensive Guide to Protective Groups in Organic Synthesis Currently Available

For more than twenty-five years, Protective Groups in Organic Synthesis has been the definitive guide for organic chemists in designing synthetic routes. Now in its fourth edition, the text continues to be a uniquely comprehensive and an indispensable reference for both synthetic organic and medicinal chemists who want to control the reactivity of the most common functional groups during a synthetic sequence.

The Fourth Edition includes significant developments in protective group chemistry since 1998. In addition to incorporating new protective groups now available to the synthetic organic chemist, such as the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines, the book also covers new techniques for the formation and cleavage of existing protective groups, providing the most relevant and useful examples to illustrate each methodology. The content is organized around the functional group to be protected (ethers, acids, carbonyl groups, amines, amides, phenols, etc.), and ranges from the simplest to the most complex highly specialized protective groups.

New features of the Fourth Edition include:

  • The addition of numerous new protective groups, such as the fluorous family
  • New methods for the cleavage and introduction of many of the classic protective groups highlighting selectivity issues when reported in the literature
  • Expanded coverage of the unexpected side reactions that occur with protective groups
  • A new chart covering the selective deprotection of silyl ethers
  • 3,100 new references from the professional literature, complete through the end of 2005

About the Author:

PETER G. M. WUTS, PHD, is a Senior Research Fellow at Pfizer in Ann Arbor, Michigan.

The late THEODORA W. GREENE, PHD, was the librarian for the Rowland Institute for Science and former assistant editor for Organic Syntheses.

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Other Popular Editions of the Same Title

9780471697541: Greene's Protective Groups in Organic Synthesis

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ISBN 10:  0471697540 ISBN 13:  9780471697541
Publisher: Wiley-Interscience, 2006
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9780471160199: Protective Groups in Organic Synthesis

Wiley-..., 1999
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9780471623014: Protective Groups in Organic Synthesis

Wiley-..., 1991
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