Structural Bioinformatics (Methods of Biochemical Analysis) - Hardcover

Hardcover

ISBN 10: 0471202002 ISBN 13: 9780471202004

Publisher: Wiley-Liss, 2003

Synopsis

From the Foreword?
"[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery."

This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies.

About this title

From the Author

This book includes chapters from many of the leaders in the field and is intended to serve as a reference text for graduate students undertaking bioinformatics as a major or any established scientist wishing to understand the field at a time when biological structure is key to our understanding of living systems.

From the Inside Flap

The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helge Weissig, this groundbreaking text provides a thorough understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics.

Structural Bioinformatics begins with chapters on the fundamentals of protein structure, DNA/RNA structure, carbohydrates, and techniques including X-ray crystallography, NMR, cryo-electron microscopy, and molecular visualization. The next section addresses data representation and databases, followed by information on structure classification of proteins (SCOP) and class, architecture, topology, and homology (CATH) classification. Later chapters cover structure-function assignment, protein interactions, and proteins as drug targets. Structural Bioinformatics also:
* Covers the theory, biology, resources, and practical applications for computational approaches to biomolecular structural studies
* Provides broad-based, concise coverage with a consistent direction
* Offers detailed coverage for practitioners while remaining accessible to the novice
* Presents computational analysis of growing masses of structural data as the key to advances in pharmacogenomics

The book concludes with several chapters on structure prediction methods, and discussion of the future of high-throughput structure determination in drug design.

Readers will gain the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Molecular biologists, biochemists, biophysicists, and bioinformaticians in basic and clinical research, as well as undergraduate and graduate students in biology, medicine, and computer science, will find Structural Bioinformatics to be an essential addition to their professional and academic libraries.

Edition details

• Publisher: Wiley-Liss
• Publication date: 2003
• ISBN 10: 0471202002
• ISBN 13: 9780471202004
• Binding: Hardcover
• Language: English
• Number of pages: 649
• Editor: Bourne Philip E., Weissig Helge