Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins - Hardcover

Hardcover

ISBN 10: 0471324418 ISBN 13: 9780471324416

Publisher: Wiley-Interscience, 1998

Synopsis

"A reference that should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data" --Science

About this title

From the Back Cover

Edited by Andreas D. Baxevanis and B. F. Francis Ouellette

Bioinformatics, a field integrating molecular biology and computational methods, has revolutionized gene discovery and related research. This new, rapidly evolving discipline provides the tools scientists need to cope with the flood of biological data and raw DNA and protein sequence information generated by such endeavors as the Human Genome Project.

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins makes computational biology accessible to scientists at all levels of expertise, including those with no formal computer training. It cuts through the overwhelming array of existing tools and databases, helping the reader design and implement a successful sequence analysis strategy. Presented by leading authorities in computational biology, this edited volume covers the gamut of topics, from using software and Internet resources to submitting DNA sequences to databases. Other topics include:

• The GenBank sequence database and structure databases
• Sequence analysis using GCG
• Information retrieval from biological databases
• The NCBI data model
• Sequence alignment and database searching
• Practical aspects of multiple sequence alignment
• Phylogenetic analysis
• Predictive methods using nucleotide sequences and protein sequences
• Navigating public physical mapping databases
• ACeDB: A database for genome information

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins is fully referenced and provides appendices, sample sequence file formats, and over 120 illustrations. A must have for molecular biologists, geneticists, and any biologist interested in genes and proteins, it can also be used in a one-semester practical course on sequence analysis and bioinformatics.

From the Inside Flap

Bioinformatics A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette With the explosion of sequence and structural information available to researchers, the field of bioinformatics is playing an increasingly large role in the study of fundamental biological problems. The challenge facing biologists, especially in light of the vast amount of data being produced by the Human Genome Project and other systematic sequencing efforts, will be the effective utilization of sequence-based information on two fronts: first, to reveal previously unknown relationships—ranging from the identification of unknown genes to the prediction of protein structures; and, second, to use predictions and inferences made from these data to better design experiments in the laboratory as genome projects move from the realm of structural genomics into one of functional genomics. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins makes computational biology accessible to scientists at all levels of expertise, including those with no formal computer training, by taking an example-driven approach accompanied by a large number of illustrations. By focusing in on a selected group of powerful methods, the book cuts through the overwhelming array of existing tools and databases, helping the reader quickly design and implement a successful sequence analysis strategy. Presented by leading authorities in computational biology, this edited volume covers a broad range of topics in bioinformatics, beginning with a gentle reintroduction to the use of software and Internet resources and culminating with a discussion of how readers can submit their own sequence data to the public databases. Other topics covered in this volume include:

• The GenBank sequence database
• Structural databases and basic tools for viewing three-dimensional structures
• Sequence analysis using the integrated GCG package
• Information retrieval from biological databases
• The NCBI data model
• Effective methodologies for performing sequence-based database searches
• Practical aspects of multiple sequence alignment
• Phylogenetic analysis
• Predictive methods using protein and nucleotide sequences
• Navigating public physical mapping databases
• The AceDB database for organizing and presenting genome information

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins is fully referenced and provides appendices, a glossary, sample sequence file formats, and over 120 illustrations. This volume is a must have for molecular biologists, geneticists, biochemists, and any other biologist interested in using sequence information to advantage in the laboratory. The topics have been arranged to build upon one another so that the book can also be used in a one-semester practical course on sequence analysis and bioinformatics.

Edition details

• Publisher: Wiley-Interscience
• Publication date: 1998
• ISBN 10: 0471324418
• ISBN 13: 9780471324416
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 370
• Editor: Baxevanis Andreas D., Ouellette B. F. Francis