Drug Discovery for Nervous System Diseases

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9780471465638: Drug Discovery for Nervous System Diseases
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The neurosciences have been an especially difficult field for drugdiscovery. Because of the huge complexity of the nervous system andpoor understanding of most psychiatric and neurological diseases,most drugs currently available are the result of chanceobservations rather than a truly comprehensive approach. However,this situation has begun to change. Enormous progress in molecularbiology has yielded breakthrough discoveries of the causes ofnervous system diseases, opening the door for better-targeted andentirely novel therapies.
Reflecting these recent advances, Drug Discovery for Nervous SystemDiseases presents the latest techniques and approaches for drugdiscovery, organizing them according to diseases rather thanclasses of drugs or drug targets, as past books have done. Writtenwith optimistic anticipation of great progress still to come, thistext provides both a guide to present realities and a look tofuture possibilities in this burgeoning field.

Coverage in Drug Discovery for Nervous System Diseasesincludes:

* Fundamentals of drug discovery-receptors, target selection, anddrug development
* Schizophrenia
* Depression
* Anxiety disorders
* Alzheimer's disease
* Parkinson's disease
* Ischemic stroke, brain, and spinal cord injury
* Other neurodegenerative diseases
* Sleep disorders
* Epilepsy
* Pain

This practical handbook features a uniform presentation for eachchapter, with a brief description of existing drugs leading torecent molecular biological and genetic findings, translationalresearch and the interface to clinical trials, and finally anoutlook on future drug targets. Rich illustrations-schematicdiagrams and tables-provide a dynamic visual experience throughoutthe text.

A unique and up-to-date guide to a field currently undergoing amajor growth spurt, Drug Discovery for Nervous System Diseasesoffers both practitioners and advanced students an unparalleledresource.

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About the Author:

Franz F. Hefti, PhD, held academic positions between 1985 and 1995, first as Associate Professor at the University of Miami, Florida, than as Professor with endowed chair at the University of Southern California in Los Angeles. He conducted pioneering research in the area of neurotrophic factors by demonstrating that these proteins can rescue dying nerve cells in the adult brain. He has served as Director of Neuroscience Research at Genentech Inc., pursuing industrial applications of his research on neurotrophic factors, leading to phase III trials with nerve growth factor. Since 1995 his activities have been dedicated to the discovery of novel drugs for neurological and psychiatric diseases in the pharmaceutical industry. From 1995 to 2001 he was Vice President at Merck Research Laboratories and Director of The Neuroscience Research Centre of Merck Sharp & Dohme. He later served as Senior Vice President of Neuroscience Research at Merck & Co.

Review:

"It is a book I enjoyed reading; it is both expression andscience." (Journal of Natural Products, October 2005)

"...an outstanding overview of the current state of drugdiscovery..." (Drug Development and Industrial Pharmacy,No. 10, 2005)

"...handy for old-timers who need a quick refresher oncurrent therapy for neurological disorders." (CurrentSeparations, August 2005)

"...highly readable and informative. The entire book iscarefully organized and very well written. It provides an excellentresource..." (American Journal of PharmaceuticalEducation, Volume 69, Issue 4, 2005)

"...recommended for all practitioners and advanced studentswho have an interest in this field." (E-STREAMS, August2005)

"...unique in providing an overview and synthesis of the currentstate of research on diseases of the nervous system, relevantpharmacological principles, and...the drug discovery process."(Doody's Book Review Service)

"The text gives an overview of the state of current research,but also gives an outlook on possible future drug targets."(Drug Discovery & Development, February 2005)

“...a marvelous text that offers the medical community anew perspective on both treatment and research....”(Electric Review, November 2004)

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Franz F. Hefti
Published by John Wiley and Sons Ltd, United States (2004)
ISBN 10: 0471465631 ISBN 13: 9780471465638
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Book Description John Wiley and Sons Ltd, United States, 2004. Paperback. Condition: New. 1. Auflage. Language: English. Brand new Book. The neurosciences have been an especially difficult field for drug discovery. Because of the huge complexity of the nervous system and poor understanding of most psychiatric and neurological diseases, most drugs currently available are the result of chance observations rather than a truly comprehensive approach. However, this situation has begun to change. Enormous progress in molecular biology has yielded breakthrough discoveries of the causes of nervous system diseases, opening the door for better-targeted and entirely novel therapies. Reflecting these recent advances, Drug Discovery for Nervous System Diseases presents the latest techniques and approaches for drug discovery, organizing them according to diseases rather than classes of drugs or drug targets, as past books have done. Written with optimistic anticipation of great progress still to come, this text provides both a guide to present realities and a look to future possibilities in this burgeoning field. Coverage in Drug Discovery for Nervous System Diseases includes: Fundamentals of drug discovery-receptors, target selection, and drug development Schizophrenia Depression Anxiety disorders Alzheimer's disease Parkinson's disease Ischemic stroke, brain, and spinal cord injury Other neurodegenerative diseases Sleep disorders Epilepsy Pain This practical handbook features a uniform presentation for each chapter, with a brief description of existing drugs leading to recent molecular biological and genetic findings, translational research and the interface to clinical trials, and finally an outlook on future drug targets. Rich illustrations-schematic diagrams and tables-provide a dynamic visual experience throughout the text. A unique and up-to-date guide to a field currently undergoing a major growth spurt, Drug Discovery for Nervous System Diseases offers both practitioners and advanced students an unparalleled resource. Seller Inventory # AAH9780471465638

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Book Description John Wiley and Sons Ltd, United States, 2004. Paperback. Condition: New. 1. Auflage. Language: English. Brand new Book. The book focuses on drug discovery for psychiatric and neurological diseases, which is in a phase of explosive growth. Chapters are divided into two major sections. The first section presents fundamentals of drug discovery, highlighting the modern techniques and approaches of drug discovery in biotech and pharmaceutical companies. Specific aspects of brain diseases, such penetration of the blood-brain barrier, are addressed. The author pays particular attention to clinical proof-of-concept research. Discussion of drug discovery for the major nervous system diseases represents the second section of the book. Each chapter looks at a particular class of disease, beginning with a summary of current understanding of disease mechanism and treatment, followed by thorough discussion of novel targets and emerging drugs. Seller Inventory # AAH9780471465638

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Book Description John Wiley and Sons Ltd, United States, 2004. Paperback. Condition: New. 1. Auflage. Language: English. Brand new Book. The book focuses on drug discovery for psychiatric and neurological diseases, which is in a phase of explosive growth. Chapters are divided into two major sections. The first section presents fundamentals of drug discovery, highlighting the modern techniques and approaches of drug discovery in biotech and pharmaceutical companies. Specific aspects of brain diseases, such penetration of the blood-brain barrier, are addressed. The author pays particular attention to clinical proof-of-concept research. Discussion of drug discovery for the major nervous system diseases represents the second section of the book. Each chapter looks at a particular class of disease, beginning with a summary of current understanding of disease mechanism and treatment, followed by thorough discussion of novel targets and emerging drugs. Seller Inventory # LIE9780471465638

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