Preimplantation Diagnosis of Genetic Disease: A New Technique for Assisted Reproduction

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9780471588245: Preimplantation Diagnosis of Genetic Disease: A New Technique for Assisted Reproduction
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Preimplantation Diagnosis of Genetic Diseases A New Technique in Assisted Reproduction Editors: Yury Verlinsky and Anver M. Kuliev For individuals with hereditary genetic disorders such as cystic fibrosis, muscular dystrophy, or hemophilia, the decision to reproduce can be a profoundly difficult and emotional problem. For specialists in reproductive medicine, this situation can raise a myriad of complex--often conflicting--ethical questions. Recently, a revolutionary approach to screening for genetic disorders has emerged, offering unique possibilities for resolving this dilemma. Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction details the latest procedures for detecting congenital disease in gametes prior to fertilization or in embryos fertilized in vitro prior to uteral implantation. This book covers current methods used in oocyte and preembryo sampling as well as the latest techniques in DNA and cytogenetic analysis in preimplantation development. This text presents detailed, practical information on such crucial topics as:
* blastomere and blastocyst biopsy for preimplanation genetic analysis
* oocyte retrieval and embryo transfer for in vitro fertilization
* preparation of necessary media and micromanipulation tools
* polymerase chain reaction techniques for DNA analysis of polar bodies and preembryos
* preimplantation cytogenetic and enzymatic analyses
* ethical issues involved in preimplantation genetic screening.
Serving as both a practical manual for current methods and a reference for future research and clinical applications, Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction provides a complete overview of this dramatic development in reproductive medicine. This book will be of interest to specialists in fertility medicine, obstetrics and gynecology, embryology, genetics, molecular biology, and cytogenetics whose work defines this new frontier in biomedical science.

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Focuses on the use of preimplantation diagnostic techniques for in vitro fertilization. Begins with a practical description of the organizational aspects of preimplantation diagnosis, and goes on to discuss how preimplantation genetic diagnosis fits within the framework of genetic services and assisted human reproduction. Covers the practical techniques involved and outlines methods for interpreting results.

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Yury Verlinsky; Anver Kuliev
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Yury Verlinsky; Anver Kuliev
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