The Art of Drug Synthesis

ISBN 13: 9780471752158

The Art of Drug Synthesis

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9780471752158: The Art of Drug Synthesis
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The Art of Drug Synthesis illustrates how chemistry, biology,pharmacokinetics, and a host of other disciplines come together toproduce successful medicines. The authors have compiled acollection of 21 representative categories of drugs, from whichthey have selected as examples many of the best-selling drugs onthe market today. An introduction to each drug is provided, as wellas background to the biology, pharmacology, pharmacokinetics, anddrug metabolism, followed by a detailed account of the drugsynthesis.

  • Edited by prominent scientists working in drug discovery forPfizer
  • Meets the needs of a growing community of researchers inpharmaceutical R&D
  • Provides a useful guide for practicing pharmaceuticalscientists as well as a text for medicinal chemistry students
  • An excellent follow-up to the very successful first book bythese editors, Contemporary Drug Synthesis, but with all newtherapeutic categories and drugs discussed.

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From the Back Cover:

DISCOVER  THE INS ANDOUTS OF DRUG SYNTHESIS, FROMIDENTIFYING A LEAD MOLECULE TO COMMERCIAL PRODUCTION.

Learn how chemistry, biology, pharmacokinetics, and a host ofother disciplines all play a role in the successful discovery ofnew drugs and therapeutics. This text features contributions fromseventeen leading medicinal and process chemists who show you howit is done. Some of the contributors were instrumental in thediscovery of the drugs they review, offering you a unique andinvaluable perspective on the complete drug discovery process.

The first two chapters of this text introduce the stringentrequirements for a potential therapeutic molecule, approaches infinding molecular structures that 'hit" a biological target, andthe many steps needed to go from initial small-scale laboratorysynthesis to commercial and the many steps needed to go frominitial small-scale laboratory synthesis to commercial production.The remaining fifteen chapters are divided into three majortherapeutic areas:

  • Cancer and infectious Diseases
  • Cardiovascular and Metabolic Diseases
  • Central Nervous System Diseases

These three section collectively cover twenty-one categories ofdrugs and more than sixty individual drugs, highlighting bothmedicinal and process synthetic routes. The authors presentdetailed accounts of the synthesis of such high-profile drugs asActos®, Levaquin®, Avelox®, Diflucan®,Tamiflu®, Zetia®, Lyrica®, and Strattera®. Yougain new insight into how a first generational agent is refined andimproved by the application of medicinal chemistry for thediscovery of second and third generation medicines.

This text is an excellent companion to the bestsellingContemporary Drug Synthesis, covering all new drugs. In addition toserving as a reference for medicinal chemists and pharmacologists,this book is highly recommended as a graduate-level text formedicinal pharmacologists, this book is highly recommended as agraduate-level text for medicinal and pharmaceutical chemistrycourses. With its many examples and insights into successful andpharmaceutical chemistry courses. With its many examples andinsights into successful syntheses, it enables students to make thebridge from theory to practice.

About the Author:

Douglas S. Johnson, PHD, is a Research Chemist at PfizerGlobal Research and Development.

Jie Jack Li, PHD, is a Research Chemist at Pfizer GlobalResearch and Development.

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Book Description John Wiley and Sons Ltd, United Kingdom, 2007. Hardback. Condition: New. 1. Auflage. Language: English . Brand New Book. The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for PfizerMeets the needs of a growing community of researchers in pharmaceutical RDProvides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry studentsAn excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed. Seller Inventory # AAH9780471752158

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Book Description John Wiley and Sons Ltd, United Kingdom, 2007. Hardback. Condition: New. 1. Auflage. Language: English . Brand New Book. The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for PfizerMeets the needs of a growing community of researchers in pharmaceutical RDProvides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry studentsAn excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed. Seller Inventory # AAH9780471752158

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