Alzheimer's Disease: Basic Mechanics, Diagnosis and Therapeutic Strategies

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9780471929277: Alzheimer's Disease: Basic Mechanics, Diagnosis and Therapeutic Strategies
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Alzheimer’s Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies Edited by Khalid Iqbal New York State Institute for Basic Research, New York, USA Donald R.C. McLachlan Centre for Research on Neurodegenerative Diseases, University of Toronto, Canada Bengt Winblad Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden and Henry M. Wisniewski New York State Institute for Basic Research, New York, USA As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Although recognized as one of the most devastating diseases of the human brain, the etiology and pathogenesis of Alzheimer’s disease are still poorly understood. Continued research is required both into the basic mechanisms of the condition and into developing diagnostic and therapeutic strategies in the clinic. Presented here is a wide-ranging, authoritative and comprehensive coverage of the most recent and significant advances in basic research and clinical investigations of Alzheimer’s disease. Areas represented include neuroimaging, brain energy metabolism, structural and molecular neuropathology, mechanisms of neuronal degeneration, role of brain amyloidosis, risk factors and epidemiology, environmental factors, genetic mechanisms, biomarkers, animal models and the clinical pharmacology of current and future therapeutic strategies. Contributions are drawn from the major research groups around the world, providing an invaluable information and reference source to both basic researchers and clinicians providing primary care for the unfortunate victims of Alzheimer’s disease. Titles of related interest from Wiley: Dahlem LS43: Etiology of Dementia of Alzheimer’s Type 0 471 92075 4 1988 Giaquinto: Aging and the Nervous System 0 471 91835 0 1988 Iqbal et al.: Alzheimer’s Disease and Related Disorders 0 471 56228 9 1989 Hindmarch, Hippius and Wilcock: Dementia: Molecules, Methods and Measures due Summer 1991

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Through the contributions of an international team of experts, this volume provides comprehensive coverage of recent advances in the basic mechanisms of Alzheimer's disease and the development of diagnostic and therapeutic strategies to treat it. Contains articles at the cutting edge of Alzheimer's disease research selected from papers presented at the Second International Conference on Alzheimer's Disease and Related Disorders. Topics covered include areas of clinical course, neuroimaging, brain energy metabolism, structural and molecular neuropathology, mechanisms of the neuronal degenerative operative, the role of brain amyloidosis, risk factors and epidemiology, environmental factors, genetic mechanisms, biomarkers, animal modes and therapeutic strategies. There are also chapters devoted to Alzheimer's disease in the developmentally disabled. This single comprehensive source for the latest information on the disease and related disorders will be a major reference for both researchers and clinicians who provide primary care to the unfortunate victims of Alzheimer's disease.

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Published by Wiley (1991)
ISBN 10: 0471929271 ISBN 13: 9780471929277
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Book Description Wiley, 1991. Condition: New. book. Seller Inventory # M0471929271

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