Cross-over Trials in Clinical Research

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9780471934936: Cross-over Trials in Clinical Research
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Statistics in Practice A new series of practical books outlining the use of statistical techniques in a wide range of application areas:

  • Human and Biological Sciences
  • Earth and Environmental Sciences
  • Industry, Commerce and Finance
Cross-over Trials in Clinical Research Stephen Senn Biometrics, Medical Department, CIBA-Geigy Ltd, Basle, Switzerland Cross-over Trials in Clinical Research provides a practical introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the methods of using cross-over designs efficiently, this book presents a fresh insight into how such trials may be designed and analysed. Key features of this comprehensive treatment are:
  • A focus on the two-period AB/BA design, including the most up-to-date developments in this topic.
  • Important aspects of special design—graphical and tabular presentation of trials, robust approaches to analysis, and practical issues in planning.
  • Direct relevance to drug development with an approach rooted firmly in biology and pharmacokinetics rather than stressing the mathematical aspects.
  • All techniques included are discussed and illustrated in detail with many practical examples drawn from the author’s wide-ranging experience.
This book will prove an invaluable reference to all statisticians and researchers in the pharmaceutical industry. It will also appeal to physicians involved in clinical research.

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From the Publisher:

Few issues in clinical trials are as controversial as the cross-over variety. Contains pertinent information on the usefulness of cross-over trials, their disadvantages, the two-stage analysis of AB/BA design and the recent revolution in attitudes to it, sequences for trials with three or more treatments, Hodges-Lehmann type estimators, various design concepts and much more. Features a significant amount of tested, practical and worked examples.

From the Back Cover:

Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages.
* Comprehensive coverage of the design and analysis of cross-over trials.

* Each technique is carefully explained and the mathematics is kept to a minimum.

* Features many real and original examples, taken from the author's vast experience.

* Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel.

* Written in a style suitable for statisticians and physicians alike.
Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.

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