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P2 Purinoceptors: Localization, Function and Transduction Mechanisms -- Symposium No. 198 - Hardcover
Synopsis
Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
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From the Back Cover
The potent biological actions of the purine nucleotides and nucleosides, adenosine and ATP, have been recognized since 1929, and the clinical effects in humans of administration of ATP have been explored since the 1950s. However, it was not until 1972 that purinergic neurotransmission was proposed, and later, in 1978, the existence of specific receptors for extracellular ATP that recognize the triphosphate nucleotide, but not adenosine, was established. These receptors have been referred to as P2 purinoceptors whereas those responding to adenosine have been termed P1 purinoceptors. Pharmacological evidence has led to further subclassification of receptor types into two major families (the P2X and P2Y types) and several subtypes within these. The P2X receptors are members of the ligand-gated ion channel superfamily whereas the P2Y receptors are seemingly members of the G protein-coupled receptor superfamily. The genes for several P2 receptor subtypes have now been cloned permitting more detailed structural and functional studies. This book covers recent advances in all major aspects of research on P2 purinoceptors. Specific topics include receptor pharmacology, transduction mechanisms, the cloning and expression of genes for the P2 purinoceptor subtypes, and the distribution and biological roles of P2 purinoceptors. The possibilities afforded by P2 purinoceptor ligands as potential therapeutic entities are also discussed.
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- PublisherWiley
- Publication date1996
- ISBN 10 0471961256
- ISBN 13 9780471961253
- BindingHardcover
- LanguageEnglish
- Edition number1
- Number of pages346
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P2 Purionoceptors : Localization, Function and Transduction Mechanisms (Ciba Foundation Symposium; 198)
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John Wiley & Sons Ltd., Chichester, West Sussex, England, 1996
ISBN 10: 0471961256
ISBN 13: 9780471961253
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hardcover. Condition: Very Good. Dust Jacket Condition: No Dust Jacket. First Edition. Symposium held at Ciba Foundation, London, 11-13 July 1995. Almost new condition. Illustrated by 72 text-figures and 14 tables. Clean Copy. Seller Inventory # 174083
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P2 Purinoceptors: Localization, Function and Transduction Mechanisms -- Symposium No. 198
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Hardcover. Condition: Très bon. Ancien livre de bibliothèque avec équipements. Edition 1996. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1996. Ammareal gives back up to 15% of this item's net price to charity organizations. Seller Inventory # G-067-174
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P2 Purinoceptors: Localization, Function and Transduction Mechanisms -- Symposium No. 198
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