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This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillation observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, pulsatile hormone signaling, and circadian rhythms in Drosophila. This book will be of interest to life scientists such as biochemists, cell biologists, chronobiologists, medical scientists and pharmacologists. In addition, it will appeal to scientists studying nonlinear phenomena, including oscillations and chaos, in chemistry, physics, mathematics and theoretical biology.
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The aim of this book is to clarify the mechanism of some of the best known rhythms at the molecular and cellular levels. The subjects considered include the enzymatic pathway that transforms sugar into ethanol in yeast in a periodic manner, and the pulsatile generation of signals of cyclic AMP, which control the rhythmic aggregation of Dictyostelium amoebae when they switch from a unicellular to a multicellular phase of development after starvation. Also considered are models for intracellular calcium oscillations and for the biochemical oscillator that controls the cell division cycle in embyonic cells.Language Notes:
Text: English (translation)
Original Language: French
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