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One of the most difficult areas of toxicology is the extrapolation of results obtained from experimental animals to man. The common occurrence of species differences in a number of biological processes confounds this extapolation. The metabolism of pesticides, drugs and other foreign compounds is a very important determinant of their toxicological effects. An understanding of species differences in metabolism and the ability to predict or to study directly the metabolic fate of a pesticide in man therefore are of great value in the validation of animal models for man. This review is concerned with the factors affecting species differences in the metabolism of foreign compounds in experimental animals and man. Additionally, specific examples of the metabolism of pesticides, drugs and industrial chemicals in man are assessed and the approaches to the execution of metabolism studies in humans, proposed.
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Book Description Wiley-Blackwell, 1991. Condition: Very Good. 1st Edition. Former Library book. Great condition for a used book! Minimal wear. Seller Inventory # GRP69563692
Book Description Wiley-Blackwell, 1991. Hardcover. Condition: Good. Item may show signs of shelf wear. Pages may include limited notes and highlighting. Includes supplemental or companion materials if applicable. Access codes may or may not work. Connecting readers since 1972. Customer service is our top priority. Seller Inventory # S_187719463
Book Description Blackwell, Oxford, 1988. Hard Cover. Condition: Very Good. No Jacket. First Edition. Previous owner's name to front free endpaper. Seller Inventory # B00002401
Book Description Blackwell Scientific Publications, U.S.A., 1988. Hardcover. Condition: Very Good. 1st Edition. Contains owner stamps, but otherwise text is unmarked. Seller Inventory # 014814
Book Description Blackwell, 1988. Hardback. Condition: VERY GOOD. 1988. Blackwell. First. Hard Cover. Book- VG, integral colour boards. 11x7.5. 120pp. Many b/w illus. One of the most difficult areas of toxicology is the extrapolation of results obtained with experimental animals to man. This review is concerned with the factors affecting species differences in the metabolism of foreign compounds in experimental animals and man. Seller Inventory # 1158665
Book Description Blackwell Scientific, Oxford., 1988. Hardcover. Condition: As New. 8vo, hardcover. No dj. As new condition. Tiny nick to upper edge of spine, otherwise, no cover wear, contents crisp, clean. Review copy- reviewer's slip laid in. vi, 120 p., illus. Seller Inventory # 1111130.48