Medical Thomas Maeder Adverse Reactions

ISBN 13: 9780688116828

Adverse Reactions

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9780688116828: Adverse Reactions

A critical analysis of the relationship among doctors, patients, the pharmaceutical industry, and the government describes the development of Chloramphenicol, the controversy over its use and side effects, and the role of the FDA in drug control. 25,000 first printing.

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From Kirkus Reviews:

Intense scrutiny of the rise and fall of the antibiotic chloramphenicol (trade name: Chloromycetin) that raises tough questions about the marketing and use of drugs. Maeder (Children of Psychiatrists, 1988; The Unspeakable Crimes of Dr. Petiot, 1980) traces the story of chloramphenicol since its development by Parke-Davis in the late 1940s. Acclaimed as a wonder drug, it was the first broad-spectrum antibiotic and was indeed potent. The problem was that in a small proportion of patients it caused aplastic anemia, a fatal blood disorder. Parke-Davis, which was a large, powerful, and highly respected pharmaceutical house in the 1940s and 1950s, promoted the drug vigorously and in glowing terms, and doctors listened and believed. Maeder recounts in great detail how, despite repeated warnings from the Food and Drug Administration and the American Medical Association, studies by the National Research Council, decades of congressional hearings, countless lawsuits, and reams of adverse publicity in both the popular press and professional journals, doctors continued to prescribe it. The book is filled with memorable passages--gruesome accounts of the deaths of children, anguished and angry letters from distraught parents, and sparring matches between Senator Estes Kefauver and the president of Parke-Davis and between Senator Gaylord Nelson and the firm's head of quality control. Today, chloramphenicol has largely disappeared in the United States (though not overseas), as other, even more potent drugs have taken its place, but the basic questions Maeder raises remain unanswered: what risks are acceptable, and how can the public be protected against unacceptable ones? Perhaps wisely, Maeder does not pretend to have the solution, but he recommends improved reporting of adverse reactions to the FDA and better controls on doctors' prescribing behavior and on promotional activities of pharmaceutical companies. Meticulously researched and documented; a valuable addendum to the literature on drug safety. -- Copyright ©1994, Kirkus Associates, LP. All rights reserved.

From Publishers Weekly:

"No drug is completely safe," cautions medical writer Meader ( Children of Psychiatrists ) in introducing this involving, instructive "biography" of one still-controversial drug, Chloromycetin, a highly profitable "miracle" antibiotic released in 1949 and administered to some 40 million Americans in the 1950s for a wide spectrum of infections ranging from dysentery to mononucleosis. Within three years, it became clear that the drug caused aplastic anemia, often fatal, in a small proportion of those taking it, and an investigation was launched by the FDA. Meader pursues the story of the drug's development, tracking its widely accepted efficacy and examining Parke-Davis's marketing campaigns; he also interviewed physicians, medical researchers and personnel of drug manufacturers and federal agencies, along with the drug's victims and their relatives. Congressional hearings about misleading promotions and inadequate warnings to physicians of the drug's danger contributed to the passage in 1962 of the Kefauver-Harris Amendments instituting tighter drug regulation.
Copyright 1994 Reed Business Information, Inc.

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Maeder, Thomas
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Maeder, Thomas
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