Robustness and Evolvability in Living Systems (Princeton Studies in Complexity) - Hardcover

Wagner, Andreas

Hardcover

ISBN 10: 0691122407 ISBN 13: 9780691122403

Publisher: Princeton University Press, 2005

Synopsis

All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness.


Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness.


Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.

About this title

About the Author

Andreas Wagner is professor of biochemistry at the University of Zurich. He studies the evolution of biological systems on all levels of organismal organization, from genes and genomes to gene networks and embryonic development

From the Back Cover

"This is a timely book that should appeal to biologists, engineers, and applied mathematicians."--David C. Krakauer, Santa Fe Institute

"This is a major contribution, addressing what are perhaps the central questions in the subject of complex adaptive systems: What makes systems robust and how does selection at different levels of organization act to shape robustness? It is a well-written, well-organized, provocative piece of scholarly work that will be widely read and debated."--Simon Levin, Princeton University

From the Inside Flap

"This is a timely book that should appeal to biologists, engineers, and applied mathematicians."--David C. Krakauer, Santa Fe Institute

"This is a major contribution, addressing what are perhaps the central questions in the subject of complex adaptive systems: What makes systems robust and how does selection at different levels of organization act to shape robustness? It is a well-written, well-organized, provocative piece of scholarly work that will be widely read and debated."--Simon Levin, Princeton University

Edition details

• Publisher: Princeton University Press
• Publication date: 2005
• Language: English
• ISBN 10: 0691122407
• ISBN 13: 9780691122403
• Binding: Hardcover
• Number of pages: 368