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One of the major breakthroughs in the treatment of cardiovascular disease has been the introduction of fibrinolytic therapy. Better knowledge of the pathogenesis of acute ischemic syndromes has identified acute thrombosis as the triggering event in most cases. Thrombosis of large and small arteries may have catastrophic consequences as sudden death, myocardial infarction, ischemic stroke, pulmonary embolism and acute limb necrosis. Fibrinolytic therapy is aimed at early restoration of occluded blood vessels thereby improving symptoms and organ recovery, reducing infarct size and subsequently improving quantity and quality of life. However, fibrinolytic drugs have severe, sometimes fatal side-effects. They mainly consist of bleeding, sometimes fatal cerebral bleeding. Therefore, stringent patient selection is mandatory: age, time to treatment, relative and absolute contraindications and comitant medication are of utmost importance for safe and efficacious fibrinolysis.
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Roger A. MacKinnon, M.D., is Professor Emeritus of Clinical Psychiatry at the College of Physicians and Surgeons of Columbia University in New York, New York.
Robert Michels, M.D., is Walsh McDermott University Professor of Medicine and Psychiatry at Weill Medical College of Cornell University in New York, New York.
Peter J. Buckley, M.D., is Professor of Psychiatry at Albert Einstein College of Medicine of Yeshiva University in Bronx, New York.
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Book Description W. B. Saunders, 1971. Hardcover. Condition: New. Dust Jacket Condition: No Dust Jacket. First Edition. 473 pages. Seller Inventory # 39379
Book Description Saunders, 1971. Hardcover. Condition: New. Never used!. Seller Inventory # P11072165973X
Book Description Saunders, 1971. Condition: New. book. Seller Inventory # M072165973X
Book Description Saunders, 1971. Hardcover. Condition: New. Seller Inventory # DADAX072165973X