Immunologic Disorders in Infants and Children

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9780721689647: Immunologic Disorders in Infants and Children

Written and edited by international experts in the field, this 5th Edition guides readers through all of the most recent advances in pediatric immunology―from development and function of the immune system...to the latest on primary and secondary immunodeficiencies...to the newest treatments and must-have advice on transplantation. Completely revised and expanded, the New Edition features two new editors, Dr. Hans Ochs and Dr. Jerry Winkelstein―plus 30 new authors―who join Dr. Stiehm in delivering up-to-the-minute information.

  • Presents two new editors and 30 new authors.
  • Features 10 new chapters, including The Natural Innate Defense System, The Immunology of Pregnancy, Apoptosis Syndromes, Periodic Fever Syndromes and more. (See Table of Contents for a complete listing.)
  • Includes new material on the immunodeficiencies of immaturity and HIV infection―two fast-moving areas.
  • Provides expanded coverage of the secondary immunodeficiencies section, including a new chapter on genetic syndromes.
  • Includes extended discussions on immunodeficiency of malnutrition, splenic deficiency, surgical and anesthetic stress, and burns.
  • Presents greater coverage of combined and isolated cellular (T-cell) immunodeficiencies...all told, it discusses over 100 primary immunodeficiencies.
  • Places more emphasis on oncology in the hematology chapter.
  • Provides an updated review of bone marrow and solid organ transplantation.

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About the Author:

MD, University of Wisconsin Medical School 1957

Affiliated at: Ronald Reagan UCLA Medical Center

Santa Monica-UCLA Medical Center and Orthopaedic Hospital

UCLA Children's Health Center

200 UCLA Medical Plaza Suite 265

Los Angeles, CA 90095

MEDICAL BOARD CERTIFICATION

Clinical & Laboratory Immunology, American Board of Allergy and Immunology, 1986

Allergy & Immunology, American Board of Allergy and Immunology, 1974

Pediatrics, American Board of Pediatrics, 1964

Fellowship: Biochemistry, University of Wisconsin Hospitals and Clinics, 1958 - 1959

Residency, Immunology, Moffitt Hospital, 1963 - 1965, Pediatrics, Columbia Presbyterian Medical Center, 1961 - 1963

Internship

Rotating Intern, Philadelphia General Hospital, 1957 - 1958

Medical Degree

MD, University of Wisconsin Medical School, 1957

2009 Special Recognition Award from the American Academy of Allergy, Asthma and Immunology (AAAAI)

Dr. E. Richard Stiehm, professor of paediatrics in the division of allergy, immunology and rheumatology at Mattel Children's Hospital at the University of California at Los Angeles (UCLA), was presented with the 2007 Abbott Laboratories Award.

From The New England Journal of Medicine:

The rapid growth in our knowledge of basic and clinical immunology is reflected in the fifth edition of Immunologic Disorders in Infants and Children. The 98 authors, including the three editors, who have contributed to this updated textbook use excellent figures to illustrate immunologic processes and many tables to summarize data in an organized manner. The development and function of the immune system is covered in part I, which starts with the ontogeny of the immune system and covers its major components. There are new chapters on the natural (innate) immune system and the immunology of pregnancy. The B-lymphocyte system is covered in two chapters -- one on basic immunology, the other on clinical immunology. The latter includes a discussion of the therapeutic use of immunoglobulin G and the evaluation of B cells and their products, the immunoglobulins. (Figure) Immunodeficiency diseases are the main emphasis in this book. An expanded discussion of more than 100 primary immunodeficiency diseases is covered in part II. The chapter on general considerations with respect to immunodeficiency disorders is an excellent overview of the cause, genetics, evaluation, and management of immunodeficiency diseases. The following chapters discuss each disorder individually, including its definition, historical aspects, pathogenesis, clinical and laboratory features, diagnosis, treatment, and prognosis. This part of the book is an excellent reference on individual immunodeficiency diseases. A new chapter on the autoimmune lymphoproliferative syndrome resulting from defects in apoptosis is also included. Secondary immunodeficiency diseases are discussed in a separate section (part III) and include updated chapters on the immunodeficiency of immaturity, immune mechanisms in infectious disease, and infection with the human immunodeficiency virus. Other chapters discuss immunodeficiency resulting from malnutrition, metabolic disorders, therapeutic and environmental immunosuppression, and stress from a variety of causes. This part of the book also contains discussions of the consequences of asplenia and immunodeficiency associated with genetic syndromes and proliferative and histiocytic disorders. The chapter on the physiologic immunodeficiency of immaturity will be of interest to all pediatricians and demonstrates the advances in our understanding of immunity and the need to learn more about the ontogeny of immune function in neonates and infants. Immune-system-mediated diseases, such as allergic diseases and autoimmunity, are covered in updated chapters in part IV, which includes a new chapter on periodic fever syndromes. Even though separate textbooks can be devoted to each of the topics, the pathogenesis, evaluation, and management of these disorders emphasize their immunologic basis. In addition, the chapters on infection in the immunocompromised host, active and passive immunization to prevent infectious diseases, and transplantation of solid organs and bone marrow have been updated to reflect the gains in knowledge and experience in these areas. This book covers most aspects of immune disorders affecting children, from basic immunology to a discussion of specific diseases and therapeutic options. It is essential reading for pediatric immunologists and trainees in immunology and an outstanding reference for pediatricians and trainees in pediatrics. Ramsay L. Fuleihan, M.D.
Copyright © 2005 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

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