Epidermolysis Bullosa: Clinical, Epidemiologic, and Laboratory Advances and the Findings of the National Epidermolysis Bullosa Registry

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9780801860249: Epidermolysis Bullosa: Clinical, Epidemiologic, and Laboratory Advances and the Findings of the National Epidermolysis Bullosa Registry

Inherited epidermolysis bullosa (EB) is a group of rare genetic diseases in which the skin is mechanically very fragile, resulting in chronic blister formation. In the most severe cases, affected persons may also experience disease involvement of other organs, cancer, and even premature death. In this book, a distinguished group of medical authorities presents the first comprehensive examination of EB employing a large, well-characterized research study population and using the latest epidemiological and biostatistical research principles. Unique to this work is its assessment of more than two thousand patients with EB, the largest such sample likely ever to be assembled in the world.

In addition to state-of-the-art reviews on basic science aspects of this disease, the book contains all of the significant original data generated on behalf of the National EB Registry Project during its first ten years of existence (1986-95); none of these data have been previously published in another peer-reviewed forum. Also included are detailed tables that will prove of value to clinicians and scientists alike as they diagnose, study, or treat individuals or groups with inherited EB.

Among the topics discussed are molecular and cell biology, epidemiology, diagnosis, classification, medical and surgical treatments, and clinical outcomes. The book will be of particular interest to dermatologists, neonatologists, pediatricians, medical geneticists, internists, oncologists, and scientists who are directly involved in the evaluation or study of EB. Although EB is a relatively rare disease, its ability to affect nearly every organ system (in severe cases) makes it of potential interest to a wide variety of medical specialists.

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About the Author:

Jo-David Fine, M.D., M.P.H., is a professor of dermatology at the School of Medicine and a clinical professor of epidemiology at the School of Public Health, University of North Carolina at Chapel Hill, and Principal Investigator and Project Head, National Epidermolysis Bullosa Registry, Chapel Hill, North Carolina. Eugene A. Bauer, M.D., is Vice President for Academic Affairs and Dean of the Stanford University School of Medicine. Joseph McGuire, M.D., is a professor of dermatology at Stanford University Medical Center. Alan Moshell, M.D., is Chief, Skin Disease Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health.

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Fine, Jo-David; Bauer, Eugene A.; McGuire, Joseph; Mosehll, Alan, eds.
Published by Johns Hopkins University Press, Baltimore (1999)
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Dr. Jo-David Fine MD MPH (Editor), Dr. Eugene A. Bauer MD (Editor), Dr. Joseph McGuire MD (Editor), Dr. Alan Moshell MD (Editor)
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