Pharmaceutical Toxicology (ULLA Postgraduate Pharmacy Series) - Softcover

Mulder Ed, Gerard J

Softcover

ISBN 10: 0853695938 ISBN 13: 9780853695936

Publisher: Pharmaceutical Press, 2006

Synopsis

The "ULLA" series is a new and innovative series of introductory textbooks for postgraduate students in the pharmaceutical sciences. This new series is produced by the ULLA Consortium (European University Consortium for Advanced Pharmaceutical Education and Research). The Consortium is a European academic collaboration in research and teaching of the pharmaceutical sciences that is constantly growing and expanding. Before a drug substance can be tested in man, a set of toxicology studies must be carried out in animals and in vitro to ensure, as far as possible, safety for the test subjects. Toxicity studies involve assessment of acute, repeated dose and chronic toxicities, evaluation of potential effects on vital organs, reproductive and developmental toxicity studies, and carcinogenicity studies. This book covers a limited number of areas of drug toxicity which address the major issues including registration requirements of new drugs and pharmacovigilance. It also provides an overview of the methodology and requirements of pre-clinical safety assessment of new medicines. Mechanisms by which drugs cause toxic effects in living organisms, and problems in the toxicity of specific agents are covered, as are regulatory issues, pharmacovigilence, and clinical toxicology. There is no other textbook at this level dedicated to pharmaceutical toxicology, and this new title in the "ULLA" series fills a definite gap in the market.

About this title

From the Back Cover:

Toxicology studies are carried out on all drug substances to ensure safety. This book provides an overview of the methodology and requirements of pre-clinical safety assessments of new medicines. With the focus on medicinal drugs - the most important safety issues of drugs are covered, including registration requirements of new drugs and pharmacovigilance. After a general introduction and a number of chapters on basic toxicological principles, organ toxicity of drugs is illustrated by chapters on toxicity in the liver, in the kidney, in the respiratory system and in the immune system. This is an introductory text for students at the BSc, MSc and PhD level, and will be an excellent companion to pharmacology textbooks, combining a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug with information on the toxicological knowledge base and methodology. Gerard J Mulder is Director of Research, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands. Lennart Dencker is Professor and Chairman of Toxicology and Dean of the Faculty of Pharmacy, Uppsala University, Sweden.

Review:

'The text is well written, concise and easy to understand with informative and helpful illustrations, figures and tables...it serves as an excellent companion to pharmacology textbooks, dealing with the issues relevant for assessing the safety of new drugs...a good starting point for the novice toxicologist, ambitious undergraduate student or graduate students working in the pharmaceutical sciences.'Irish Pharmacy Journal, November 2006, p418 (Irish Pharmacy Journal)

'...this is a great little book...the text is aimed primarily at new PHD students in the pharmaceutical and related sciences but could equally well serve taught postgraduate students on toxicology, clinical pharmacology, drug development and safety or similar courses. The book 'does exactly what it says on the tin' and will definitely whet the appetite of enthusiastic young researchers for toxicology.'Heather M Wallace, Summer 2007 issue of the British Toxicology Society Newsletter (Heather M Wallace British Toxicology Society Newsletter)

About this edition

• Publisher: Pharmaceutical Press
• Publication date: 2006
• ISBN 10: 0853695938
• ISBN 13: 9780853695936
• Binding: Paperback
• Edition number: 1
• Number of pages: 257