Protein Structure and Function

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9780878936632: Protein Structure and Function

Published by New Science Press and distributed in the U.S. and Canada by Oxford University Press

This text introduces general principles of protein structure, folding, and function, then goes beyond these basics to tackle the conceptual basis of inferring structure and function from genomic sequence. It is the first book in a series, Primers in Biology, employing a modular design in which chapters are divided into topics, each occupying one two-page spread that includes the relevant text, illustrations (in full color), definitions, and references.

The book has five chapters. The first is an introduction to the principles of protein structure and folding, with emphasis on proteins' biophysical properties. The second describes the principles of the main biochemical functions of proteins, namely binding and catalysis, with a short section on the properties of structural proteins. Chapter 3 covers the regulation of protein function, containing concise descriptions of all the regulatory mechanisms that operate on proteins, from pH to phosphorylation, with several sections on protein switches based on nucleotide hydrolysis. Chapter 4 introduces the principles whereby structure and function are deduced from sequence, with illustrative examples. The final chapter addresses how data on protein structure is gathered, interpreted, and presented.

Written for upper-level undergraduates and beginning graduate students, Protein Structure and Function is also be for working scientists needing an up-to-date introduction to the field.

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About the Author:


Gregory A. Petsko studied chemistry and classics as an undergraduate at Princeton University before going to Oxford as a Rhodes scholar to work for his Ph.D. with David Phillips. He then pursued his interest in the mechanism of enzyme catalysis at the Massachusetts Institute of Technology, where he taught courses in chemistry and detective fiction. Currently the Director of the Rosenstiel Center at Brandeis, he has extended his research interests to include the use of yeast genetics to study the unfolded protein response pathway, and the mechanism of action of the ABC transporter proteins.

Dagmar Ringe graduated in chemistry from Barnard College, Columbia, and took her Ph.D. in bioorganic chemistry from Boston University. She then pursued her research interest in the study of enzyme catalysis by X-ray crystallography at the Massachusetts Institute of Technology before moving to Brandeis, where she is Professor of Biochemistry and Chemistry. The principal focus of Dr. Ringe's research is structure-function relationships in enzymes of particular industrial and pharmaceutical importance.

Review:


"I have not encountered a book better than this one for students interested in learning more about structure-function relationships in proteins."
--B. Williams, Choice


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Book Description Sinauer Associates Inc.,U.S., United States, 2004. Paperback. Book Condition: New. Language: English . Brand New Book. Protein Structure and Function is an introduction for postgenomic biologists to the structural basis for the biological activities of proteins, with special emphasis on the interpretation of gene sequence in terms of protein function. Early chapters discuss the determinants of folding and stability and of secondary, tertiary and quaternary structure, the universe of protein folds, and superfamilies and motifs in the analysis of protein function, as well as the basic principles of protein function, with major sections on ligand binding and enzyme catalysis. Later chapters describe the regulation of protein function and how proteins work as switches, machines and motors, and discuss the contribution of comparative structural analysis to the understanding of the relationship between sequence, structure and function. The book ends with a short chapter on how the structures of proteins are determined. Bookseller Inventory # AAS9780878936632

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Book Description Sinauer Associates Inc.,U.S., United States, 2004. Paperback. Book Condition: New. Language: English . Brand New Book. Protein Structure and Function is an introduction for postgenomic biologists to the structural basis for the biological activities of proteins, with special emphasis on the interpretation of gene sequence in terms of protein function. Early chapters discuss the determinants of folding and stability and of secondary, tertiary and quaternary structure, the universe of protein folds, and superfamilies and motifs in the analysis of protein function, as well as the basic principles of protein function, with major sections on ligand binding and enzyme catalysis. Later chapters describe the regulation of protein function and how proteins work as switches, machines and motors, and discuss the contribution of comparative structural analysis to the understanding of the relationship between sequence, structure and function. The book ends with a short chapter on how the structures of proteins are determined. Bookseller Inventory # AAS9780878936632

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Book Description Sinauer Associates Inc.,U.S., United States, 2004. Paperback. Book Condition: New. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. Protein Structure and Function is an introduction for postgenomic biologists to the structural basis for the biological activities of proteins, with special emphasis on the interpretation of gene sequence in terms of protein function. Early chapters discuss the determinants of folding and stability and of secondary, tertiary and quaternary structure, the universe of protein folds, and superfamilies and motifs in the analysis of protein function, as well as the basic principles of protein function, with major sections on ligand binding and enzyme catalysis. Later chapters describe the regulation of protein function and how proteins work as switches, machines and motors, and discuss the contribution of comparative structural analysis to the understanding of the relationship between sequence, structure and function. The book ends with a short chapter on how the structures of proteins are determined. Bookseller Inventory # BTE9780878936632

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Book Description Sinauer Associates Inc.,U.S. Paperback. Book Condition: new. BRAND NEW, Protein Structure and Function, Gregory A. Petsko, Dagmar Ringe, Protein Structure and Function is an introduction for postgenomic biologists to the structural basis for the biological activities of proteins, with special emphasis on the interpretation of gene sequence in terms of protein function. Early chapters discuss the determinants of folding and stability and of secondary, tertiary and quaternary structure, the universe of protein folds, and superfamilies and motifs in the analysis of protein function, as well as the basic principles of protein function, with major sections on ligand binding and enzyme catalysis. Later chapters describe the regulation of protein function and how proteins work as switches, machines and motors, and discuss the contribution of comparative structural analysis to the understanding of the relationship between sequence, structure and function. The book ends with a short chapter on how the structures of proteins are determined. Bookseller Inventory # B9780878936632

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