Neurodegenerative Disorders: The Role Played by Endotoxins and Xenobiotics

 
9780881674507: Neurodegenerative Disorders: The Role Played by Endotoxins and Xenobiotics

The human nervous system represents the most complex and sensitive level of biological organization in nature. As such, its function can be influenced by minor derangements of either the internal homeostasis or the external environment. In virtually all neurodegenerative conditions, the various pathogenic processes selectively affect certain groups of neurons, leaving others intact. The reasons for such selectivity are unknown, and theories proposed to explain them mostly rest on speculative ground. However, recent advances in neurobiology, particularly in the field of genetics, biochemistry, and pharmacology/toxicology, have shed light on the pathogenesis of several of these disorders. This volume is the result of an initial gathering together of a group of experts in neurodegenerative disorders ranging from biochemistry to clinical aspects. The book addresses issues in this intriguing and fascinating field in an unconventional way by combining in-depth reviews, reports of new findings, and proposals of challenging hypotheses. The book is divided into sections dealing with the toxic hypothesis of aging and dementia and the toxicology of parkinsonian syndromes and of choreiform and dystonic conditions, motor neuron diseases, and peripheral nerve degenerations. The last section is dedicated to ethanol. The chapters on the quinolinic acid hypothesis of neurodegenerative disorders, on MPTP, on cycas circinalis extracts exemplify how clinicians with scientifically inquiring minds and scientists with scrutinizing eyes attentive to clinical problems can integrate information crucial to the advancement of medical sciences. The book is addressed predominantly to specialists in neurology, neurobiology, and toxicology, but several chapters should help the neophyte in the field to understand the background of the most accredited theories and the major controversies in this rapidly expanding field.

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1.

Giuseppe Nappi (Editor)
Published by Raven Press (1987)
ISBN 10: 0881674508 ISBN 13: 9780881674507
Used Hardcover Quantity Available: 1
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killarneybooks
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Book Description Raven Press, 1987. Hardcover. Book Condition: Good. Hardcover, xvii + 326pp, b&w figures in text, subject index. Weight: 0.77kg/1.7lb. A foreign university library withdrawal with corresponding internal marking (a bookplate inside front board, cancelled/stamped label on half-title page, a blank label on title page and a couple of large stamps on its reverse; a small circular stamp in lower margin of two text pages; prelims with minor traces of erased pencil inventory notations). Interior shows small marks from reading, remains in clean, bright, untanned condition with unmarked text. A portion of leaves with gently curled tips of corners. Good secure binding throughout. Faint dusty storage marks to outer page edges. Vinyl boards show shelfwear, moderate wear to gilt lettering, a scratch to lower front, numerous scratches to upper section of rear panel. Short creases to upper and lower spine ends. Published without a dust jacket. --- Boards show some really minor handling wear. --- Fast priority airmail from Ireland. --- The human nervous system represents the most complex and sensitive level of biological organization in nature. As such, its function can be influenced by minor derangements of either the internal homeostasis or the external environment. In virtually all neurodegenerative conditions, the various pathogenic processes selectively affect certain groups of neurons, leaving others intact. The reasons for such selectivity are unknown, and theories proposed to explain them mostly rest on speculative ground. However, recent advances in neurobiology, particularly in the field of genetics, biochemistry, and pharmacology/toxicology, have shed light on the pathogenesis of several of these disorders. This volume is the result of an initial gathering together of a group of experts in neurodegenerative disorders ranging from biochemistry to clinical aspects. The book addresses issues in this intriguing and fascinating field in an unconventional way by combining in-depth reviews, reports of new findings, and proposals of challenging hypotheses. The book is divided into sections dealing with the toxic hypothesis of aging and dementia and the toxicology of parkinsonian syndromes and of choreiform and dystonic conditions, motor neuron diseases, and peripheral nerve degenerations. The last section is dedicated to ethanol. The chapters on the quinolinic acid hypothesis of neurodegenerative disorders, on MPTP, on cycas circinalis extracts exemplify how clinicians with scientifically inquiring minds and scientists with scrutinizing eyes attentive to clinical problems can integrate information crucial to the advancement of medical sciences. The book is addressed predominantly to specialists in neurology, neurobiology, and toxicology, but several chapters should help the neophyte in the field to understand the background of the most accredited theories and the major controversies in this rapidly expanding field. Bookseller Inventory # 002550

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2.

Nappi Giuseppi; Oleh Hornykiewicz; Ruggero G Fariello; Allesandro Agnoli; Harold Klawans (editors)
Published by Raven Press, New York (1988)
ISBN 10: 0881674508 ISBN 13: 9780881674507
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Cellar Stories Bookstore
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Book Description Raven Press, New York, 1988. Hardcover. Book Condition: Very Good. 326 pp. 8vo. Hardocver. Light scuffing, minor scratching. Bumping to spine ends and upper corners. Light soiling to textblock and ep's. Pp. 215-260 detached in 2 sections but glued back into binding by seller. Bookseller Inventory # 135898

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