Advances in the understanding of skeletal morphogenesis and growth have not been systematically applied to our understanding of clinical problems in orthopaedics. This new work should enable physicians to take full advantage of recent scientific progress to develop new, more effective treatment options. It seems clear that a fresh range of alternatives will develop from our understanding of pathogenesis and the response of cells and tissues to specific treatments. In this volume of the Symposium Series, more than 35 orthopaedic surgeons, cell and molecular biologists, and bioengineers, define current clinical issues and knowledge, identify potential applications for basic concepts to clinical problems, and list specific directions for future research. The work is based on a 1977 workshop sponsored by the Academy of Orthopaedic Surgeons, the Orthopaedic Research and Education Foundation, and the NIH.
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