Cell Death and Diseases of the Nervous System (Contemporary Neuroscience)

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9780896034136: Cell Death and Diseases of the Nervous System (Contemporary Neuroscience)
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It is an honor to be asked to write a foreword for this timely book, which assembles contributions from authorities working in the area of pathological nervous system cell death, and has been expertly edited by Vassilis Koliatsos and Rajiv Ratan. That the inap­ propriate demise of brain or spinal cord cells is at the root of many neurological diseases has been appreciated since the early days of microscopic neuropathology, but it has only been in the last decade or so that pervasive therapeutic nihilism has lifted. In the journey of medical progress, we have reached the shores of a marvelous new land. Three major scientific thrusts in particular have converged to produce the press of ideas covered here. First, burgeoning information about the fundamental nature of central nervous system cell--(;ell signaling, both the fast signaling mediated by conventional neu­ rotransmitters and the usually slower signaling mediated by neuromodulators and growth factors. A central theme emerging in recent years has been the duality of these signaling mechanisms, which serve the nervous system in health, but which can become the very mediators of neuronal or glial cell degeneration in disease settings. Glutamate-mediated neurotransmission and excitotoxicity have been the defining and best-studied examples, but many other examples have also emerged. Second, delineation of the molecular under­ pinnings of programmed cell death, and an appreciation of their awesome power.

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Written by pioneers in the field, Cell Death and Diseases of the Nervous System captures all the important classic and new research on neuronal injury and cell death and the application of these results to the treatment of a wide range of neurological and neuropsychiatric illness. The outcome is a unique integration of cellular and molecular insights, clinical knowledge, and therapeutic experience. As the chapters move back and forth from the basic to the clinical level, exciting possibilities emerge for finding therapeutic approaches to neurological illness based on a new understanding of fundamental processes. Extensive cross-referencing allows easy navigation between chapters and different points of view.

Cell Death and Diseases of the Nervous System provides a concise summary of current neurological knowledge from the perspective of the basic disease mechanisms involved in neuronal injury and death. In an era of increasing specialization, this book offers an authoritative integration and unique cross-fertilization for all those seeking to better understand and treat neurological illness.

Review:

" Overall, this is a sound book with well-recognized authors whose expertise spans the field of neurodegenerative disorders. It is a valuable resource for graduate students and for those who have previously limited their focus to a particular neurological disorder...Collectively, the authors paint a sufficiently lucid picture of the sequence of events involved in neurodegenerative processes...Cell Death and Diseases of the Nervous System must be considered to be one of the top books in the rapidly growing literature on neurodegenerative disorders."-Trends in Neuros cience

"This book undertakes an extensive review of the fast moving field of cell death, an area of neurobiology that is currently the center of intensive investigation both at the level of mechanisms and disease pathogenesis....It is thus a book that will interest both neuroscientists and neurologists alike...will be a useful addition to the libraries of neurologists with an interest in neurodegenerative disorders, although other neurological conditions associated with neuronal death are touched on (for example, viral encephalitis, HIV-1 infection, trauma, and schizophrenia) which may widen its appeal.-Journal of Neurology, Neurosurgery, and Psychiatry

"...appeal to a wide spectrum of readers in both the laboratory and clinical setting....The first part on cellular and molecular mechanisms provides a wonderful overview of this difficult matter, ...In part II, a selection of animal models is reviewed, while part III extensively discusses cell death in acute and chronic conditions....This volume broadly covers the field of neuronal death, and the large number of (mostly) up to date references make this a very useful textbook. Being written and edited by authorities in the field, it can be strongly recommended."-Acta Neurologica Belgica

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