The Physical and Chemical Basis of Molecular Biology: Fundamentals

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9780956478139: The Physical and Chemical Basis of Molecular Biology: Fundamentals

The subject of molecular biology continues to be the most exciting and dynamic area of science and is predicted to dominate the 21st century. Only by investigating biological phenomena at the molecular level is it possible to understand them in detail. This volume describes the most fundamental aspects of molecular biology: thermodynamics for molecular biology (equilibrium constants, Gibbs free energy, coupled reactions, linked functions, enthalpy, entropy, heat capacity, and calorimetry), noncovalent interactions between atoms and molecules (molecular surfaces, electrostatic interactions, dipoles, van der Waals interactions, hydrogen bonds, intramolecular interactions, effective concentrations, and cooperativity), aqueous solutions (liquid water, hydrophobic interaction, partition coefficients, membranes, detergents, ionization, pH, buffers, salts and ions, solubilities, salting in, salting out, Hofmeister series, hydration, chemical potential, compressibility), kinetics (rate constants, half-time, relaxation time, transition state, free energy relationships, multi-step reactions and intermediates, rate-determining step, the steady state, and rapid reactions), isotopes and radioactivity (radioactive decay, alpha particles, beta particles, positrons, gamma rays, scintillation counters, Cerenkov radiation, autoradiography, fluorography, kinetic isotope effects, and hydrogen exchange), and mass spectrometry (electrospray ionization, ESI, matrix-assisted laser desorption/ionization, MALDI, quadropole mass analyzers, time-of-flight analyzers, Fourier transform ion cyclotron resonance, FTMS, tandem mass spectrometry). These six chapters are taken from the larger volume The Physical and Chemical Basis of Molecular Biology (2010, Helvetian Press, ISBN 978-0-9564781-0-8).

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About the Author:

Thomas E. Creighton is retired, after a career in academia at Caltech, Stanford and Yale Universities, the MRC Laboratory of Molecular Biology (MRC-LMB) at Cambridge, England, and the European Molecular Biology Laboratory (EMBL) at Heidelberg, Germany. He is the author of two editions of Proteins: Structures and Molecular Properties published by W.H. Freeman and of The Physical and Chemical Basis of Molecular Biology and The Biophysical Chemistry of Nucleic Acids & Proteins by Helvetian Press. He has edited the four-volume Encyclopedia of Molecular Biology and the five-volume Encyclopedia of Molecular Medicine for Wiley-Interscience, two editions of Protein Structure: A Practical Approach and Protein Function: A Practical Approach for IRL Press at Oxford University Press, and the volume Protein Folding for W.H. Freeman.

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Thomas E. Creighton
Published by Helvetian Press (2011)
ISBN 10: 0956478131 ISBN 13: 9780956478139
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