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Synopsis
Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.
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Book Description
An ideal resource for anyone conducting lab-based biomedical research, this guide shows how to design reproducible experiments that have low bias, high precision and widely applicable results. It explores key ideas in experimental design, including reproducibility and replication, assesses common designs, and shows how to plan for success.
About the Author
Stanley E. Lazic holds a PhD in Neuroscience and a Masters degree in Computational Biology from the University of Cambridge and has conducted research at the University of Oxford, the University of Cambridge, and Harvard University, Massachusetts. He has written several papers on reproducible research and the design and analysis of biological experiments, and has published in Science and Nature. He is currently a Team Leader in Quantitative Biology (Statistics) at AstraZeneca.
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- PublisherCambridge University Press
- Publication date2017
- ISBN 10 1107424887
- ISBN 13 9781107424883
- BindingPaperback
- LanguageEnglish
- Edition number1
- Number of pages422
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Experimental Design for Laboratory Biologists: Maximising Information and Improving Reproducibility
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Experimental Design for Laboratory Biologists
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Experimental Design for Laboratory Biologists
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