Studies concerning glycosuria and diabetes

9781235867606: Studies concerning glycosuria and diabetes
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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1913 Excerpt: ...injections twice daily. In this way the temperature was kept up to 40 degrees for six hours. Schlutz, whose paper is most recent, worked at Finkelstein's suggestion, using rabbits. He reports a personal communication from Finkelstein, to the effect that the latter now believes that lactose acts by fermentation, injuring the intestinal wall and thus bringing about an abnormal metabolism of salts. Schlutz confirms Helmholz in finding fever after 3 out of 5 intravenous injections of distilled water, due to the liberation of pyrogenic substances frjom destroyed blood-cells. He gave lactose in varying concentration by mouth, subcutaneously and intravenously. In some of the mouth-experiments, /3-oxybutyric acid or croton oil was used to irritate the intestine. The doses of sugar, as a rule, were large, up to 50 cc. of 50 per cent solution. Fever was slight, brief, variable, frequently absent. The author concludes that lactose possesses no distinct pyrogenic action alone, but may affect the temperature if given with a sodium salt (physiologic or Ringer solution) in a diseased intestinal tract. Discussion. Experiments. It is possible to form a clear and simple idea of the mechanism of the fever caused by salt or sugar. These substances under certain conditions injure cells, and the injured cells give off products which act upon the nervous system to cause fever. That the sugar or salt itself does not by entering the circulation cause the fever, is proved by the fact that intravenous injections of salt or sugar cause less fever than subcutaneous injections of the same; also by the negative results of Schlutz with lactose, all of which must circulate through the system until finally excreted by the kidneys. That products of injured cells cause the fever is well shown...

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