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Brian Henderson is Professor of Cell Biology in the Division of Microbial Diseases, Eastman Dental Institute and in the Division of Infection and Immunity, University College London. He has been working on the cell-cell signalling actions of molecular chaperones since 1994 when his group identified a potent bone-destroying protein produced by an oral bacterium as the cell stress protein, chaperonin (hsp)60. His studies have focused on the intercellular signalling actions of hsp60 and hsp10 proteins from various sources and on the anti-inflammatory activity of thioredoxin. In collaboration with Graham Pockley he has edited a postgraduate volume on the signalling activity of molecular chaperones entitled Molecular Chaperones and Cell Signalling, Cambridge University Press 2005.
Michael Cheetham is Professor of Molecular Cell Biology at the Institute of Ophthalmology, University College London and has worked on chaperones since he identified the first human Hsp70 cochaperone (HSJ1) in 1991. He has since worked on several cochaperones and has focused on the role of chaperones in the retina and nervous system and in degenerative disease.
A. Graham Pockley is Professor of Immunobiology in the University of Sheffield Medical School. His interests lie in the significance of extracellular molecular chaperones to inflammatory disease processes and his group has been working in this area since first discovering the presence of Hsp60 and Hsp70 in the peripheral circulation of healthy individuals in the late 1990s. Graham has published a number of reviews on circulating cell stress proteins in Lancet and Circulation and has edited a book on molecular chaperones as cell signalling molecules with Brian Henderson.
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