Anti-Apoptotic Activity of the Herpes Simplex Virus Type 2 Gene ICP10 PK: Implications for the Therapy of Neurological Disorders That Involve Apoptosis

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9781449991319: Anti-Apoptotic Activity of the Herpes Simplex Virus Type 2 Gene ICP10 PK: Implications for the Therapy of Neurological Disorders That Involve Apoptosis
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PhD Thesis (2002). Apoptosis is an etiologic component of neurodegenerative disorders [e.g. Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS)] and acute brain injury ischemia/hypoxia and trauma). Previous studies have shown that a Herpes Simplex Virus Type 2 (HSV-2) gene, ICP10 PK, activates the Ras/MEK/ERK pathway in non-neuronal cells. Because this pathway was implicated in neuronal cell survival, the present studies tested whether ICP10 PK blocks apoptosis in various experimental paradigms of neuronal apoptosis. The broad anti-apoptotic activity of ICP10 PK suggests that it may be used in gene therapy of neurological disorders that involve apoptosis. In addition, the gene can be delivered non-invasively to the central nervous system using a replication-deficient HSV-2 mutant (ICP10deltaRR).

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Book Description Createspace Independent Publishing Platform, United States, 2009. Paperback. Condition: New. Language: English . Brand New Book ***** Print on Demand *****. PhD Thesis (2002). Apoptosis is an etiologic component of neurodegenerative disorders [e.g. Alzheimer s disease (AD), amyotrophic lateral sclerosis (ALS)] and acute brain injury ischemia/hypoxia and trauma). Previous studies have shown that a Herpes Simplex Virus Type 2 (HSV-2) gene, ICP10 PK, activates the Ras/MEK/ERK pathway in non-neuronal cells. Because this pathway was implicated in neuronal cell survival, the present studies tested whether ICP10 PK blocks apoptosis in various experimental paradigms of neuronal apoptosis. The broad anti-apoptotic activity of ICP10 PK suggests that it may be used in genetherapy of neurological disorders that involve apoptosis. In addition, the gene can be delivered non-invasively to the central nervous system using a replication-deficient HSV-2 mutant (ICP10deltaRR). Seller Inventory # APC9781449991319

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Book Description Createspace Independent Publishing Platform, United States, 2009. Paperback. Condition: New. Language: English . Brand New Book ***** Print on Demand *****.PhD Thesis (2002). Apoptosis is an etiologic component of neurodegenerative disorders [e.g. Alzheimer s disease (AD), amyotrophic lateral sclerosis (ALS)] and acute brain injury ischemia/hypoxia and trauma). Previous studies have shown that a Herpes Simplex Virus Type 2 (HSV-2) gene, ICP10 PK, activates the Ras/MEK/ERK pathway in non-neuronal cells. Because this pathway was implicated in neuronal cell survival, the present studies tested whether ICP10 PK blocks apoptosis in various experimental paradigms of neuronal apoptosis. The broad anti-apoptotic activity of ICP10 PK suggests that it may be used in genetherapy of neurological disorders that involve apoptosis. In addition, the gene can be delivered non-invasively to the central nervous system using a replication-deficient HSV-2 mutant (ICP10deltaRR). Seller Inventory # APC9781449991319

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Book Description CreateSpace Independent Publishing Platform. Paperback. Condition: New. This item is printed on demand. 334 pages. Dimensions: 10.0in. x 8.0in. x 0.8in.PhD Thesis (2002). Apoptosis is an etiologic component of neurodegenerative disorders e. g. Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS) and acute brain injury ischemiahypoxia and trauma). Previous studies have shown that a Herpes Simplex Virus Type 2 (HSV-2) gene, ICP10 PK, activates the RasMEKERK pathway in non-neuronal cells. Because this pathway was implicated in neuronal cell survival, the present studies tested whether ICP10 PK blocks apoptosis in various experimental paradigms of neuronal apoptosis. The broad anti-apoptotic activity of ICP10 PK suggests that it may be used in gene therapy of neurological disorders that involve apoptosis. In addition, the gene can be delivered non-invasively to the central nervous system using a replication-deficient HSV-2 mutant (ICP10deltaRR). This item ships from La Vergne,TN. Paperback. Seller Inventory # 9781449991319

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