Recent Advances in Immunoassays - Softcover

Kundu Ph.D., Dr. Samar K

Softcover

ISBN 10: 1500744395 ISBN 13: 9781500744397

Publisher: CreateSpace Independent Publishing Platform, 2014

Synopsis

Immunoassay is a biochemical method that measures the presence or concentration of an analyte referred as an antigen in a solution through the use of an antibody or immunoglobulin. Immunoassays are now very widely used in the clinical laboratory, either because no other type of assay system is feasible or because they are often the most effective and suitable of the possible analytical methods. The major trend has been away from liquid-phase assays involving radioisotopic labels, towards fast homogeneous or solid-phase assays capable of operation anywhere; and towards precise and reliable non-isotopic, automated or semi-automated laboratory assays, often with detection limits measured in pico- or attomoles. The use of monoclonal antibodies is now widespread, and the methodologies of labels and of solid-phase components are much more sophisticated. New assay formulations, novel homogeneous systems, immunosensors, free-analyte assays, ultra-sensitive detection systems are being developed. Recent trends has been to enhance the sensitivity of the assays that may also have applications in measurement of other tumor markers, providing earlier detection of cancer or of relapse, Alzheimer’s disease and in measurement of certain cardiac markers. More importantly, it is believed that high-sensitivity assays are expected to enable about a 50-fold expansion in the number of protein markers that can be analyzed in the clinical lab. At present, due to the sensitivity limitations of existing immunoassays of about 10-15 molar, only about 2,000 proteins are routinely analyzed by clinical labs. However, about 100,000 proteins are believed to exist in human blood, most of which are not analyzed due to limitations of existing assays. New high-sensitivity tests could potentially drive a significant expansion of the immunoassay market by enabling an entirely new set of markers to be analyzed. The present book is intended to overview different immunoassays including the most recent development trend.

About this title

About the Author:

The author Dr. Samar K Kundu received his Ph.D. in Organic Chemistry and D.Sc. in Bio-organic Chemistry from the Calcutta University. During his forty five years of research and development, he has published over 65 scientific papers in reputed international journals and books. He was credited with 15 US patents and 25 International patents. He has given numerous lectures in the United States and other countries. His academic career started at the University of Calcutta as a Reader in Chemistry, at the Albert Einstein College of Medicine, Bronx, New York as a Visiting Assistant Professor in Biochemistry and Immunology and at the Baylor College of Medicine, Houston, Texas in Biochemistry and Experimental Medicine as an Assistant Professor. He then began his career in Industrial Research and Development in the Diagnostic Division of the Abbott Laboratories, Abbott Park, Illinois as a Senior Scientist and later on he was inducted to the prestigious Volweiler Society as a Fellow. During the period at Abbott, he was an editor (NIH) for National Institute of Health (USA) Cholesterol Management Program, Consultant to United Nations Development Program (UNDP) in Immunodiagnostics., Visiting Professor at the Institute of Chemical Biology, Jadavpur, Kolkata, and Visiting Advisor for WHO at the National Institute of Immunology, New Delhi. He was recognized in WHO’S WHO in Marquis Frontier’s in Science and Technology and in Men of Achievement, UK. Apart from his new innovation in Research and Development, he acquired extensive experience and implemented in the Quality System Regulation (QSR), Good Manufacturing Practice (GMP), Test Method Validation and others in in-vitro diagnostic products. Presently, the author is a Chief Scientist at the Sword Diagnostics and has developed new innovative technology for the ultrasensitive

About this edition

• Publisher: CreateSpace Independent Publishing Platform
• Publication date: 2014
• ISBN 10: 1500744395
• ISBN 13: 9781500744397
• Binding: Paperback
• Number of pages: 134