Direct Detection of Alpha Synuclein Oligomers in vivo

0 avg rating
( 0 ratings by Goodreads )
 
9781516835041: Direct Detection of Alpha Synuclein Oligomers in vivo

Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. We have developed a unique animal model that provides a tool for the Parkinson’s disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers. Proceeds from the sale of this book go to the support of an elderly disabled person.

"synopsis" may belong to another edition of this title.

Buy New View Book
List Price: US$ 380.00
US$ 271.59

Convert Currency

Shipping: US$ 3.99
Within U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Applied Research Press
ISBN 10: 1516835042 ISBN 13: 9781516835041
New Quantity Available: > 20
Print on Demand
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description 2015. PAP. Book Condition: New. New Book.Shipped from US within 10 to 14 business days.THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # IP-9781516835041

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 271.59
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

2.

Applied Research Press
ISBN 10: 1516835042 ISBN 13: 9781516835041
New Quantity Available: > 20
Print on Demand
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description 2015. PAP. Book Condition: New. New Book. Delivered from our US warehouse in 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND.Established seller since 2000. Bookseller Inventory # IP-9781516835041

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 282.54
Convert Currency

Add to Basket

Shipping: US$ 11.92
From United Kingdom to U.S.A.
Destination, Rates & Speeds

3.

Applied Research Press
Published by Createspace Independent Publishing Platform, United States (2015)
ISBN 10: 1516835042 ISBN 13: 9781516835041
New Paperback Quantity Available: 10
Print on Demand
Seller:
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description Createspace Independent Publishing Platform, United States, 2015. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****. Rat models of Parkinson s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. We have developed a unique animal model that provides a tool for the Parkinson s disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers. Bookseller Inventory # APC9781516835041

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 339.46
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Applied Research Press
Published by Createspace Independent Publishing Platform, United States (2015)
ISBN 10: 1516835042 ISBN 13: 9781516835041
New Paperback Quantity Available: 10
Print on Demand
Seller:
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Createspace Independent Publishing Platform, United States, 2015. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Rat models of Parkinson s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. The detection of alpha- synuclein oligomers, the presumed toxic species, in these models and others has been possible using only indirect biochemical approaches to date. Here we coinjected AAVs encoding alpha-synuclein fused to the N- or C-terminal half of VenusYFP in rat substantia nigra pars compacta and describe for the first time a novel viral vector rodent model with the unique ability to directly detect and track alpha synuclein oligomers ex vivo and in vivo. We have developed a unique animal model that provides a tool for the Parkinson s disease research community with which to directly detect alpha- synuclein oligomers in vivo and screen therapeutic approaches targeting alpha-synuclein oligomers. Bookseller Inventory # APC9781516835041

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 350.32
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds