Proapoptotic Activity of Ukrain is Based on Chelidonium Majus L. Alkaloids and Mediated via a Mitochondrial Death Pathway

 
9781517347888: Proapoptotic Activity of Ukrain is Based on Chelidonium Majus L. Alkaloids and Mediated via a Mitochondrial Death Pathway
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The anticancer drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L. alkaloid chelidonine and the alkylans thiotepa was reported to exert selective cytotoxic effects on human tumour cell lines in vitro. Few clinical trials suggest beneficial effects in the treatment of human cancer. Aim of the present study was to elucidate the importance of apoptosis induction for the antineoplastic activity of Ukrain, to define the molecular mechanism of its cytotoxic effects and to identify its active constituents by mass spectrometry. The potent proapoptotic effects of Ukrain are not due to the suggested "Ukrain-molecule" but to the cytotoxic efficacy of Chelidonium majus L. alkaloids including chelidonine. Proceeds from the sale of this book go to support an elderly disabled person.

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