Systemic Treatment with CAR-Engineered T Cells Against PSCA Delays Subcutaneous Tumor Growth and Prolongs Survival of Mice

 
9781517349417: Systemic Treatment with CAR-Engineered T Cells Against PSCA Delays Subcutaneous Tumor Growth and Prolongs Survival of Mice

Adoptive transfer of T cells genetically engineered with a chimeric antigen receptor (CAR) has successfully been used to treat both chronic and acute lymphocytic leukemia as well as other hematological cancers. Experimental therapy with CAR-engineered T cells has also shown promising results on solid tumors. The prostate stem cell antigen (PSCA) is a protein expressed on the surface of prostate epithelial cells as well as in primary and metastatic prostate cancer cells and therefore a promising target for immunotherapy of prostate cancer. Our data confirms that PSCA-CAR T cells may be developed for treatment of prostate cancer. Proceeds from the sale of this book go to support an elderly disabled person.

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