Breast Cancer Patients with Lobular Cancer More Commonly Have a Father Than a Mother Diagnosed with Cancer

 
9781517350642: Breast Cancer Patients with Lobular Cancer More Commonly Have a Father Than a Mother Diagnosed with Cancer
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The association between lobular breast cancer and family history is not clear. The aim of the study was to possibly identifying new hereditary patterns predisposing for cancer in the different histopathologic subtypes of breast cancer, with focus on patients with lobular breast cancer and cancer in their first degree relatives. We propose that lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate carcinoma. Since the association remained after excluding family history of breast cancer, the association seems independent of classical breast cancer heredity. The association with a father diagnosed with cancer also remained after removing prostate cancer, indicating an independence from prostate cancer as well. The reason for this association is genetically unclear, but could involve sex-specific imprinting. Proceeds from the sale of this book go to the support of an elderly disabled person.

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