Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)

0 avg rating
( 0 ratings by Goodreads )
 
9781584885306: Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)
View all copies of this ISBN edition:
 
 

Maintaining a practical perspective, Bioequivalence and Statistics in Clinical Pharmacology explores statistics used in day-to-day clinical pharmacology work. The book covers the methods needed to design, analyze, and interpret bioequivalence trials; explores when, how, and why these studies are performed as part of drug development; and demonstrates the proposed methods using real world examples.

Drawing on knowledge gained directly from working in the pharmaceutical industry, the authors set the stage by describing the general role of statistics. Once the foundation of clinical pharmacology drug development, regulatory applications, and the design and analysis of bioequivalence trials are established, they move on to related topics in clinical pharmacology involving the use of cross-over designs. These include, but are not limited to, safety studies in Phase I, dose-response trials, drug interaction trials, food-effect and combination trials, QTc and other pharmacodynamic equivalence trials, and dose-proportionality trials. Purposefully designed to be instantly applicable, the book provides examples of SAS code so that the analysis described can be immediately implemented. The authors have made extensive use of the proc mixed procedures available in SAS.

Each chapter includes a vignette based on co-author Scott Patterson's experience in the clinical pharmacology work place and all the data sets are taken from real trials. The authors delineate practical utility and objectives, provide real-world examples of the topic under discussion, and include statistical theory and applications. Technical theory, where extensive, is included in technical appendices at the end of the chapter. Each topic contains worked examples that illustrate the applications of the statistical techniques and their interpretation. The authors also develop statistical tools useful for other topics of clinical pharmacology - namely general safety testing, testing for proarrythmic potential, population pharmacokinetics, and dose-selection.

"synopsis" may belong to another edition of this title.

Review:

I really enjoyed reading this book. Each chapter includes an excellent introduction based on Scott Patterson's experience working as a biometrician. This will especially be of interest to young statisticians starting their career in the pharmaceutical industry. Therefore, I strongly recommend this book to all pharmaceutical statisticians to learn more of the challenging statistical problems being generated in drug development. In addition, the presented material provides a springboard for all scientists from academia who are looking to do research in this area of medical applications.
- Dieter Haushcke, writing in Biometrics, September, 2006

The authors formulate bioequivalence exhaustively and clearly. ...Given the background of the authors, they constitute a key piece of social information in understanding the context in which clinical pharmacology research develops within the pharmaceutical industry.
-Journal of Biopharmaceutical Statistics

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 135.00
US$ 162.00

Convert currency

Shipping: US$ 3.99
Within U.S.A.

Destination, rates & speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Scott D. Patterson, Byron Jones
Published by Chapman and Hall/CRC (2005)
ISBN 10: 1584885300 ISBN 13: 9781584885306
New Hardcover Quantity Available: 1
Seller:
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Chapman and Hall/CRC, 2005. Hardcover. Condition: New. 1. Seller Inventory # DADAX1584885300

More information about this seller | Contact this seller

Buy New
US$ 162.00
Convert currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, rates & speeds

2.

Scott D. Patterson; Byron Jones
ISBN 10: 1584885300 ISBN 13: 9781584885306
New Quantity Available: 1
Seller:
BennettBooksLtd
(San Diego, CA, U.S.A.)
Rating
[?]

Book Description Condition: New. New. Seller Inventory # STR-1584885300

More information about this seller | Contact this seller

Buy New
US$ 165.07
Convert currency

Add to Basket

Shipping: US$ 4.95
Within U.S.A.
Destination, rates & speeds

3.

Scott D. Patterson; Byron Jones
Published by Chapman and Hall/CRC (2005)
ISBN 10: 1584885300 ISBN 13: 9781584885306
New Hardcover Quantity Available: 1
Seller:
Irish Booksellers
(Portland, ME, U.S.A.)
Rating
[?]

Book Description Chapman and Hall/CRC, 2005. Condition: New. book. Seller Inventory # M1584885300

More information about this seller | Contact this seller

Buy New
US$ 215.33
Convert currency

Add to Basket

Shipping: US$ 3.27
Within U.S.A.
Destination, rates & speeds

4.

Morgan, Byron J.T. (Series edited by)/ Keiding, Niels (Series edited by)/ Van der Heijden, Peter (Series edited by)/ Speed, Terry (Series edited by)/ Patterson, Scott D. (Author)/ Jones, Byron (Author)
Published by Chapman & Hall (2005)
ISBN 10: 1584885300 ISBN 13: 9781584885306
New Hardcover Quantity Available: 1
Seller:
Revaluation Books
(Exeter, United Kingdom)
Rating
[?]

Book Description Chapman & Hall, 2005. Hardcover. Condition: Brand New. 1st edition. 374 pages. 9.50x6.00x0.75 inches. In Stock. Seller Inventory # zk1584885300

More information about this seller | Contact this seller

Buy New
US$ 223.59
Convert currency

Add to Basket

Shipping: US$ 9.56
From United Kingdom to U.S.A.
Destination, rates & speeds

5.

Scott D. Patterson
Published by Chapman and Hall/CRC (2005)
ISBN 10: 1584885300 ISBN 13: 9781584885306
New Hardcover Quantity Available: 1
Seller:
Books Express
(Portsmouth, NH, U.S.A.)
Rating
[?]

Book Description Chapman and Hall/CRC, 2005. Hardcover. Condition: New. 1. Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. Buy with confidence, excellent customer service!. Seller Inventory # 1584885300n

More information about this seller | Contact this seller

Buy New
US$ 361.28
Convert currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, rates & speeds