Platelets and Megakaryocytes: Volume 1: Functional Assays (Methods in Molecular Biology)

0 avg rating
( 0 ratings by Goodreads )
 
9781588291011: Platelets and Megakaryocytes: Volume 1: Functional Assays (Methods in Molecular Biology)
View all copies of this ISBN edition:
 
 

12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

"synopsis" may belong to another edition of this title.

From the Back Cover:

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precursor, the megakaryocyte. In Platelets and Megakaryocytes, Volume 1: Functional Assays, leading expert researchers-many responsible for seminal discoveries in the field-describe basic and advanced techniques for analyzing platelet and megakaryocyte function in step-by-step detail. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. Techniques presented for megakaryocyte function research include those used to study the development of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Platelets and Megakaryocytes, Volume 2: Perspectives and Techniques offers a state-of-the-art survey of our understanding of these cells, with emphasis on the role of cell signaling in their regulation and function, as well as the use of molecular and post-genomic techniques for their study.
Comprehensive and cutting-edge, the two volumes of Platelets and Megakaryocytes offer novice and experienced cell biologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.

Review:

"...thorough and detailed...contains useful information regarding the study of platelets and megakaryocytes." - Veterinary Pathology

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 229.00
US$ 43.25

Convert Currency

Shipping: FREE
From India to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 2
Seller:
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Condition: New. New. US edition. Perfect condition. Customer satisfaction our priority. Seller Inventory # ABE-FEB-101057

More information about this seller | Contact this seller

Buy New
US$ 43.25
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

2.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 2
Seller:
EBOOKSTORE2010
(New Delhi, ND, India)
Rating
[?]

Book Description Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Seller Inventory # SHUB101057

More information about this seller | Contact this seller

Buy New
US$ 43.30
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

3.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 2
Seller:
Basi6 International
(Irving, TX, U.S.A.)
Rating
[?]

Book Description Condition: Brand New. New, US edition. Excellent Customer Service. Seller Inventory # ABEUSA-101057

More information about this seller | Contact this seller

Buy New
US$ 45.87
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

4.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Hardcover Quantity Available: 5
Seller:
bookscollection
(Delhi, DELHI, India)
Rating
[?]

Book Description Condition: Brand New. HARDCOVER, Book Condition New, U.S. EDITION. We Do not Ship APO FPO AND PO BOX. . Printing in English language.NO CD AND ACCESS CODE. Quick delivery by USPS/UPS/DHL/FEDEX/ARAMEX ,Customer satisfaction guaranteed. We may ship the books from Asian regions for inventory purpose. Seller Inventory # ABE ORG##CB11333

More information about this seller | Contact this seller

Buy New
US$ 48.00
Convert Currency

Add to Basket

Shipping: US$ 4.32
From India to U.S.A.
Destination, Rates & Speeds

5.

Jonathan M. Gibbins (Editor), Martyn P. Mahaut-Smith (Editor)
Published by Humana Press (2004)
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Hardcover Quantity Available: 1
Seller:
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Humana Press, 2004. Hardcover. Condition: New. 2004. Seller Inventory # DADAX1588291014

More information about this seller | Contact this seller

Buy New
US$ 62.22
Convert Currency

Add to Basket

Shipping: US$ 4.99
Within U.S.A.
Destination, Rates & Speeds

6.

Published by Humana Press
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Hardcover Quantity Available: 1
Seller:
Ohmsoft LLC
(Lake Forest, IL, U.S.A.)
Rating
[?]

Book Description Humana Press. Condition: New. Hardcover. Worldwide shipping. FREE fast shipping inside USA (express 2-3 day delivery also available). Tracking service included. Ships from United States of America. Seller Inventory # 1588291014

More information about this seller | Contact this seller

Buy New
US$ 93.53
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

7.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 5
Seller:
firstbookstore
(New Delhi, India)
Rating
[?]

Book Description Condition: Brand New. Brand New Original US Edition, Perfect Condition. Printed in English. Excellent Quality, Service and customer satisfaction guaranteed!. Seller Inventory # AIND-29585

More information about this seller | Contact this seller

Buy New
US$ 101.21
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

8.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 1
Seller:
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Condition: New. New. US edition. Perfect condition. Customer satisfaction our priority. Seller Inventory # ABE-FEB-101058

More information about this seller | Contact this seller

Buy New
US$ 102.37
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

9.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 1
Seller:
EBOOKSTORE2010
(New Delhi, ND, India)
Rating
[?]

Book Description Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Seller Inventory # SHUB101058

More information about this seller | Contact this seller

Buy New
US$ 102.42
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

10.

Gibbins J.M.
ISBN 10: 1588291014 ISBN 13: 9781588291011
New Quantity Available: 5
Seller:
Romtrade Corp.
(STERLING HEIGHTS, MI, U.S.A.)
Rating
[?]

Book Description Condition: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship fro the US or other locations in India depending on your location and availability. Seller Inventory # AUSBNEW-29585

More information about this seller | Contact this seller

Buy New
US$ 106.41
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book