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Oxidative Stress: Clinical and Biomedical Implications

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9781600218880: Oxidative Stress: Clinical and Biomedical Implications
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There is an emerging concept that nitric oxide (NO), its derivatives and reactive oxygen intermediates (ROS) are the major determinants of the involvement of oxidant stress that contributes to the control of physiological cell signalling processes, blood flow regulation and pathological hypoxia. This book discusses about this topic.

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Matata, Bashir M. (EDT); Elahi, Maqsood M. (EDT)
Published by Nova Science Pub Inc (2007)
ISBN 10: 1600218881 ISBN 13: 9781600218880
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Matata, Bashir M. (EDT); Elahi, Maqsood M. (EDT)
Published by Nova Science Pub Inc (2007)
ISBN 10: 1600218881 ISBN 13: 9781600218880
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Matata, Bashir M.
Published by Nova Science Publishers Inc (2007)
ISBN 10: 1600218881 ISBN 13: 9781600218880
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Bashir M. Matata
Published by Nova Biomedical Books, New York (2007)
ISBN 10: 1600218881 ISBN 13: 9781600218880
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Book Description Hardcover. Condition: new. Hardcover. There is an emerging concept that nitric oxide (NO), its derivatives and reactive oxygen intermediates (ROS) are the major determinants of the involvement of oxidant stress that contributes to the control of physiological cell signalling processes, blood flow regulation and pathological hypoxia. There is recent published evidence for additional functions of these oxygen metabolites in cardiac gene expression; functions that include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis as well as immuno-deviating effects. In vitro and in vivo experimental models investigating the biological nature of ROS have shown that there is a concentration dependent effect of NO and that differences in cell sensitivity to NO may have an impact upon the degree of immune or inflammatory state. Disturbances in NO bio-availability leads to loss of cardioprotective actions within biological systems and in some cases may even increase oxidative stress and disease progression. Hence, considerable interest in identifying the mechanisms involved in their generation and implications have spurted in the hope that inhibition strategies can be developed either bio-materially or pharmacologically. This book brings together the emerging biological concepts of oxidative stress and its connotation in the pathogenesis of various inflammatory processes in biological systems. Presents the biological concepts of oxidative stress and its connotation in the pathogenesis of various inflammatory processes in biological systems. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9781600218880

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Bashir M. Matata
Published by Nova Biomedical Books, New York (2007)
ISBN 10: 1600218881 ISBN 13: 9781600218880
New Hardcover Quantity: 1
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Book Description Hardcover. Condition: new. Hardcover. There is an emerging concept that nitric oxide (NO), its derivatives and reactive oxygen intermediates (ROS) are the major determinants of the involvement of oxidant stress that contributes to the control of physiological cell signalling processes, blood flow regulation and pathological hypoxia. There is recent published evidence for additional functions of these oxygen metabolites in cardiac gene expression; functions that include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis as well as immuno-deviating effects. In vitro and in vivo experimental models investigating the biological nature of ROS have shown that there is a concentration dependent effect of NO and that differences in cell sensitivity to NO may have an impact upon the degree of immune or inflammatory state. Disturbances in NO bio-availability leads to loss of cardioprotective actions within biological systems and in some cases may even increase oxidative stress and disease progression. Hence, considerable interest in identifying the mechanisms involved in their generation and implications have spurted in the hope that inhibition strategies can be developed either bio-materially or pharmacologically. This book brings together the emerging biological concepts of oxidative stress and its connotation in the pathogenesis of various inflammatory processes in biological systems. Presents the biological concepts of oxidative stress and its connotation in the pathogenesis of various inflammatory processes in biological systems. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. Seller Inventory # 9781600218880

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