Progress in sequencing and characterizing the human genome has transformed cancer genetics both conceptually and methodologically. In Prostate Cancer: Biology, Genetic, and the New Therapeutics, Second Edition, leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer, as well as its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth, progression and stromal-epithelial interaction has revealed many possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differntiation therapies, and gene therapy.
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Public awareness of prostate cancer has substantially increased over the past decade. Screening based on the measurement of prostate-specific antigen in serum has revolutionized the detection and management of prostate cancer. Therapeutic options include surgery, radiation therapy, and hormonal therapy, but specialists in prostate cancer have been unable to formulate clear guidelines for choosing one over another. Because of the complexity of the problem, there is a plethora of books written for the lay public, but there are few textbooks for physicians that review recent advances in basic and clinical aspects of prostate cancer.
For this reason, Prostate Cancer is a welcome addition to the literature. The book is dedicated to Donald Coffey, Ph.D., who has made important contributions to the field and has trained many researchers in prostate cancer. He is a role model for many in academic medicine.
The main strength of this book is that experts from several disciplines have contributed their thoughts on recent advances in prostate cancer. After an introductory chapter, the book has three sections; the first covers the genetics of prostate cancer, the second biologic aspects, and the third treatment approaches. The highlights of the section on genetics include chapters on familial prostate cancer and on the study of gene expression in prostate cancer with the use of gene-array libraries. This section also covers genetic alterations, molecular epidemiology, and polymorphisms of androgen receptors in prostate cancer.
The section on biology comprehensively covers cell-cell and cell-matrix interactions and cellular signaling pathways in prostate cancer. The chapter on tyrosine kinases is of particular interest, since these molecules may hold special promise for the treatment of prostate cancer, as they have for the treatment of other malignant conditions. The chapter on stromal-epithelial interaction in prostate cancer is also important, since there is a growing recognition of the role of the microenvironment in the progression of tumors.
The section on treatment nicely covers prevention, surgical therapy, and radiation therapy. This section also includes chapters on experimental protocols, mainly for the treatment of advanced prostate cancer; antiprogression agents such as short-chain fatty acids and vitamin D analogues may hold special promise for the treatment of prostate cancer. The chapter on trials of chemopreventive agents is particularly important, since many patients self-prescribe these natural and synthetic medications, and physicians need to have a better understanding of their mechanisms of action and efficacy. There is also an increasing effort to examine the role of chemopreventive agents in the treatment of prostate cancer.
I strongly recommend this book to researchers who study prostate cancer, whether at the bench or at the bedside, and to clinicians who treat patients with prostate cancer. Most of the chapters include references with publication dates as recent as 2000. Overall, the book covers our current knowledge of prostate cancer and its treatment and helps define the foundation for future directions.
Aria F. Olumi, M.D.
Copyright © 2002 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
"...the editors have done a remarkable job in selecting the topics and compiling the various articles into a comprehensive and easily accessible volume. The chapters are concise and informative, covering highly innovative studies being conducted in the field of recent years...the complexity of prostate cancer biology is well represented in the book, and the resourceful information can benefit not only those who are interested in prostate biology, but also those researchers employing molecular and cellular approaches to solve other important biological questions." - Quarterly Review of Biology
"...a welcome addition to the literature...The main strength of this book is that experts from several disciplines have contributed their thoughts on recent advances in prostate cancer...I strongly recommend this book to researchers who study prostate cancer, whether at the bench or at the bedside, and to clinicians who treat patients with prostate cancer... the book covers our current knowledge of prostate cancer and its treatment and helps define the foundation for future directions." - New England Journal of Medicine
"Well researched and extensively referenced, the book provides a valuable source of information on the current state of understanding of the molecular biology of prostate cancer, and the treatment modalities in routine clinical practice." - ACP News
"Each chapter is presented in a way that provides all available knowledge on the subject and the book structure allows readers to use a single section or chapter according to their interests. All these characteristics make the book a valuable tool to general oncologists or urologists interested in updating their basic knowledge of prostate cancer." -Annals of Oncology
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Book Description Springer, 2008. Paperback. Book Condition: New. Bookseller Inventory # SONG160327510X