Biomechanics and Mechanobiology of the Lumbar Spine: Computational Approaches: From Research to In Silico Medicine

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9781785480898: Biomechanics and Mechanobiology of the Lumbar Spine: Computational Approaches: From Research to In Silico Medicine

Biomechanics and Mechanobiology of the Lumbar Spine: Computational Approaches: From Research to In Silico Medicine aims to outline how major decision points-such as goal-adapted numerical approximations-infer in the capability of lumbar spine models to provide valuable cause-and-effect relationships in the study of organ conditions and treatments.

The spine presents an astonishing balance between mechanical resistance and flexibility in the human body, provided by complex interactions that are extremely difficult to restore when altered in disease. Given that these interactions are difficult to assess in situ, designing efficient treatments for low back pain remains a grand challenge in medicine.

Along with more than 10 years of activity in research, the book's author has explored in-depth the capability of finite element models to capture the functional load transfers within the lumbar spine. Readers of this book will find useful guidelines for model developments in both research and clinical applications.



  • Offers an overview of modeling approaches for the development of lumbar spine finite element models towards different types of applications
  • Evaluates methods based on commonly accepted techniques and the most advanced modeling solutions
  • Uniquely links simulation techniques and practical knowledge on the functional biomechanics of the lumbar spine
  • Outlines how major decision points―such as goal-adapted numerical approximations―infer in the capability of lumbar spine models to provide valuable insight for organ conditions and treatments

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About the Author:

Jérôme Noailly began his PhD in 2002 at the Universitat Politècnica de Catalunya (UPC). He explored the mechanical communications within the lumbar spine through finite element modelling, and addressed model approximation and reliability issues. In 2009, this work received the best PhD thesis award in engineering from the UPC. From 2007 to 2011, Jérôme was a Marie Sklodowska-Curie postdoctoral fellow, first at the AO Research Institute, and then at the Institute for Bioengineering of Catalonia (IBEC). During this time, he focused on soft tissue and multiphysics modeling, and in 2012 he became the head of IBEC’s group of Biomechanics and Mechanobiology until he eventually moved to the Universitat Pompeu Fabra (UPF) by early 2015.

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