Cancer Risks Associated With Elevated Levels of Drinking Water Arsenic Exposure (Awwa Research Foundation Reports)

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9781843399179: Cancer Risks Associated With Elevated Levels of Drinking Water Arsenic Exposure (Awwa Research Foundation Reports)
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In 2001 the U.S. Environmental Protection Agency (EPA) reduced the maximum contaminant level (MCL) for arsenic in drinking water from 50 g/L to 10 g/L, with the new MCL to take effect in 2006. This new MCL affects many U.S. community water systems located in areas of the country with high naturally-occurring arsenic in surface and ground water. Because of the expense of removing arsenic and the large number of systems affected, the costs of compliance with the new standard will place an economic burden on many small communities. EPA estimates that implementation of the revised arsenic standard will prevent between 6.9 and 33 bladder and lung cancer deaths each year. Recent epidemiological studies in Argentina and the United States, however, raise questions about the scientific justification for the revised arsenic MCL. In addition, although recent studies have failed to detect expected arsenic-related cancer risks, there are indications that EPA intends to further lower the arsenic MCL to below 10 g/L. Several states, including California and New Jersey, have already begun the process of lowering their arsenic MCL to below 10 g/L and California is considering implementing a standard below 1 g/L (1 part per billion). This study identified U.S. counties in which the mean drinking water arsenic level was 10 g/L or greater during 1950-1999. We conducted a multi-level, hierarchical analysis of county standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs). The objective of this study was to examine whether lung and bladder cancer incidence or mortality rates are elevated in United States populations consuming drinking water that exceeds the new EPA MCL for arsenic

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F. J. Frost
Published by Iwa Publishing, United Kingdom (2005)
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Book Description Iwa Publishing, United Kingdom, 2005. Paperback. Condition: New. Language: English . Brand New Book ***** Print on Demand *****.In 2000, the USEPA reduced the drinking water arsenic MCL from 50 ?g/L to 10 ?g/L, affecting many U.S. community water systems. This study was conducted because of the large number of systems involved, the costs of compliance with the new standard, and the increasingly uncertain scientific basis for the regulation. Two large, recently conducted studies of low-dose drinking water arsenic exposures do not support the need for the regulation. The objective of this project was to examine whether lung and bladder cancer mortality or incidence rates are elevated in U.S. populations consuming drinking water that exceeds the new USEPA MCL for arsenic of 10 ?g/L. This study took place in two phases. In the first phase, the research team estimated the mean drinking water arsenic level of most U.S. counties and identified counties with a mean arsenic level >10 ?g/L and >20 ?g/L. In the second phase, they evaluated the relationships between lung and bladder cancer mortality (1950?1999) and incidence (1973?1999) in these populations using multi-level, hierarchical statistical models (i.e., MLwiN statistical software). The research team employed three approaches: (1) combining all cancer deaths for all ages across the decades (1950?1990) for which data were available, (2) conducting a subanalysis limited to the population age 50 years and older, and (3) combining cancer deaths for those decades (1960?1999) for which comparable census variables were available. Arsenic in drinking water at levels >10 ?g/L was not associated with greater mortality from bladder or lung cancer, nor was a higher level of arsenic associated with greater incidence of bladder or lung cancer. There was considerable variation between counties in both lung and bladder cancer mortality. County lung and bladder cancer mortality rates were strongly related to neighboring county lung and bladder cancer mortality rates. This relation suggests that making an adjustment for neighboring county cancer mortality rates controls the unmeasured confounding factors. Higher mortality rates for bladder and lung cancer were observed in counties designated as metropolitan and, for males, counties with a high percentage of persons employed in manufacturing. Lower mortality rates were observed in counties with higher mean educational levels and counties with a larger mean household size. These same covariate relationships were not apparent in the incidence analysis. This study did not find evidence of increased risk for lung or bladder cancer mortality or incidence from exposure to arsenic in drinking water. The findings are consistent with other recent studies of the health effects of low dose arsenic exposure and are inconsistent with the USEPA predictions of excess cancer risk from low dose arsenic exposure. Multi-level hierarchical analysis is a highly appropriate method for determining if areas with elevated drinking water contaminants have elevated health risks. It makes optimal use of existing data in a cost-effective analysis that adjusts for many covariates. It is an approach that should be considered for addressing future drinking water health effects issues. In particular, this study adds to the literature on low dose arsenic health effects, providing the first summary of mortality and cancer incidence in U.S. populations exposed to elevated drinking water arsenic. It should provide some reassurance to customers of many drinking water utilities. Originally published by AwwaRF for its subscribers in 2004. This publication can also be purchased and downloaded via Pay Per View on Water Intelligence Online - click on the Pay Per View icon below. Seller Inventory # AAV9781843399179

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F. J. Frost
Published by Iwa Publishing, United Kingdom (2005)
ISBN 10: 1843399172 ISBN 13: 9781843399179
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Book Description Iwa Publishing, United Kingdom, 2005. Paperback. Condition: New. Language: English. Brand new Book. In 2000, the USEPA reduced the drinking water arsenic MCL from 50 ?g/L to 10 ?g/L, affecting many U.S. community water systems. This study was conducted because of the large number of systems involved, the costs of compliance with the new standard, and the increasingly uncertain scientific basis for the regulation. Two large, recently conducted studies of low-dose drinking water arsenic exposures do not support the need for the regulation. The objective of this project was to examine whether lung and bladder cancer mortality or incidence rates are elevated in U.S. populations consuming drinking water that exceeds the new USEPA MCL for arsenic of 10 ?g/L. This study took place in two phases. In the first phase, the research team estimated the mean drinking water arsenic level of most U.S. counties and identified counties with a mean arsenic level >10 ?g/L and >20 ?g/L. In the second phase, they evaluated the relationships between lung and bladder cancer mortality (1950?1999) and incidence (1973?1999) in these populations using multi-level, hierarchical statistical models (i.e., MLwiN statistical software). The research team employed three approaches: (1) combining all cancer deaths for all ages across the decades (1950?1990) for which data were available, (2) conducting a subanalysis limited to the population age 50 years and older, and (3) combining cancer deaths for those decades (1960?1999) for which comparable census variables were available. Arsenic in drinking water at levels >10 ?g/L was not associated with greater mortality from bladder or lung cancer, nor was a higher level of arsenic associated with greater incidence of bladder or lung cancer. There was considerable variation between counties in both lung and bladder cancer mortality. County lung and bladder cancer mortality rates were strongly related to neighboring county lung and bladder cancer mortality rates. This relation suggests that making an adjustment for neighboring county cancer mortality rates controls the unmeasured confounding factors. Higher mortality rates for bladder and lung cancer were observed in counties designated as metropolitan and, for males, counties with a high percentage of persons employed in manufacturing. Lower mortality rates were observed in counties with higher mean educational levels and counties with a larger mean household size. These same covariate relationships were not apparent in the incidence analysis. This study did not find evidence of increased risk for lung or bladder cancer mortality or incidence from exposure to arsenic in drinking water. The findings are consistent with other recent studies of the health effects of low dose arsenic exposure and are inconsistent with the USEPA predictions of excess cancer risk from low dose arsenic exposure. Multi-level hierarchical analysis is a highly appropriate method for determining if areas with elevated drinking water contaminants have elevated health risks. It makes optimal use of existing data in a cost-effective analysis that adjusts for many covariates. It is an approach that should be considered for addressing future drinking water health effects issues. In particular, this study adds to the literature on low dose arsenic health effects, providing the first summary of mortality and cancer incidence in U.S. populations exposed to elevated drinking water arsenic. It should provide some reassurance to customers of many drinking water utilities. Originally published by AwwaRF for its subscribers in 2004. This publication can also be purchased and downloaded via Pay Per View on Water Intelligence Online - click on the Pay Per View icon below. Seller Inventory # AAV9781843399179

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Frost, Floyd J.
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Book Description AwwaRF, 2016. Paperback. Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Seller Inventory # ria9781843399179_lsuk

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Book Description AWWARF. Paperback. Condition: New. 92 pages. Dimensions: 10.8in. x 8.1in. x 0.1in.In 2001 the U. S. Environmental Protection Agency (EPA) reduced the maximum contaminant level (MCL) for arsenic in drinking water from 50 gL to 10 gL, with the new MCL to take effect in 2006. This new MCL affects many U. S. community water systems located in areas of the country with high naturally-occurring arsenic in surface and ground water. Because of the expense of removing arsenic and the large number of systems affected, the costs of compliance with the new standard will place an economic burden on many small communities. EPA estimates that implementation of the revised arsenic standard will prevent between 6. 9 and 33 bladder and lung cancer deaths each year. Recent epidemiological studies in Argentina and the United States, however, raise questions about the scientific justification for the revised arsenic MCL. In addition, although recent studies have failed to detect expected arsenic-related cancer risks, there are indications that EPA intends to further lower the arsenic MCL to below 10 gL. Several states, including California and New Jersey, have already begun the process of lowering their arsenic MCL to below 10 gL and California is considering implementing a standard below 1 gL (1 part per billion). This study identified U. S. counties in which the mean drinking water arsenic level was 10 gL or greater during 1950-1999. We conducted a multi-level, hierarchical analysis of county standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs). The objective of this study was to examine whether lung and bladder cancer incidence or mortality rates are elevated in United States populations consuming drinking water that exceeds the new EPA MCL for arsenic This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Seller Inventory # 9781843399179

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