Extracellular and Intracellular Signaling (Drug Discovery Series, Volume 10) - Hardcover

Hardcover

ISBN 10: 1849731608 ISBN 13: 9781849731607

Publisher: Royal Society of Chemistry, 2011

Synopsis

Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. They are causative agents for diseases including hypertension, diabetes, heart disease, and arthritis so offer new, and often more approachable, targets for drug design. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets. Written by colleagues at the same institution, but with contributions from leading international authorities, it is the result of close cooperation between the authors of different chapters. Readers are introduced to a new approach to disease causation by adipokines and toxic lipids. Heart disease, migraines, stroke, Alzheimer's disease, diabetes, cancer, and arthritis are approached from the perspective of prevention and treatment by alteration of extracellular signalling. Evidence is presented that the avoidance of toxic lifestyles can reduce the incidence of such illnesses and new therapeutic targets involving adipokines, ceramide and endocannabinoids are discussed.

About this title

About the Author

James David Adams, Jr. has over 160 peer reviewed publications and abstracts to his name and has written two books. He is the Editor of several journals and has reviewed many manuscripts for journals and grant applications. Dr Adams received his PhD in Pharmacology from the University of California at San Francisco and has 22 years of experience as a faculty member in a School of Pharmacy. He has taught many Pharmacy Students, Medical Students and Physicians in Hospitals and consulted for various Pharmaceutical Companies. An undergraduate degree in Psychology at Montana State University triggered Keith K. Parker's interest in the nervous system and led to graduate work in pharmacology at UCSF, where he completed his Ph.D. He then undertook two post-doctoral research posts in Denver. The first was at the Department of Pharmacology in the University of Colorado Health Science Center, and the second was at the University of Denver Department of Chemistry. He has been at The University of Montana since 1993 and is an expert on serotonin receptors and migraine headaches.

From the Back Cover

Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are vital to the process and have been largely ignored in other works on signaling. They are causative agents in hypertension, diabetes, heart disease, arthritis and other diseases. Aimed at medical professionals and pharmaceutical specialists, this book integrates for the first time extracellular and intracellular signaling processes and offers a fresh perspective on new targets for drug development. With contributions from leading international authorities, it is the result of close cooperation between the authors of the various chapters. Readers are introduced to a new approach to disease causation by adipokines and toxic lipids. Heart disease, migraines, stroke, Alzheimer's Disease, diabetes, cancer, and arthritis are approached from the perspective of toxic lifestyles and accumulation of toxic proteins and lipids. Evidence is presented that by alterations in toxic lifestyles you can reduce the incidence of such diseases. New therapeutic targets involving adipokines, ceramide and endocannabinoids are also discussed.

Edition details

• Publisher: Royal Society of Chemistry
• Publication date: 2011
• ISBN 10: 1849731608
• ISBN 13: 9781849731607
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 303
• Editor: Adams James D, Parker Keith