Isotope Dilution Mass Spectrometry: RSC (Issues in Toxicology)

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9781849733335: Isotope Dilution Mass Spectrometry: RSC (Issues in Toxicology)
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Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique.


The main objective of this book is to cover the theory and applications of Isotope Dilution in Analytical Chemistry. The scope is comprehensive to include elemental analysis, speciation analysis, organic analysis and biochemical and clinical analysis together with applications in metabolism studies and traceability of goods. Until now there have been no books published with the same general scope (only book chapters on particular applications). This is a textbook focused at post-graduate level covering the basic knowledge required for doctoral studies in this field. Isotope Dilution Mass Spectrometry will also outline practical applications of interest for routine testing laboratories where isotope dilution procedures are implemented or can be implemented in the future. This unique book covers all the theoretical and practical aspects of Isotope Dilution Mass Spectrometry (IDMS). Due to the increasing application of IDMS in many research laboratories and the increasing implementation of IDMS methodologies in routine testing laboratories, scientists in industry and working in or affiliated to this area will this an invaluable source of information. Concerning the theoretical aspects, the authors present a uniform theoretical background which grows from previous developments in Organic, Speciation and Elemental analysis both in their own laboratory and in other laboratories around the world. This general approach will be simpler and will also include new emerging fields such as quantitative proteomics and metabolism studies.

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Isotope Dilution Mass Spectrometry (IDMS) is increasingly used in research laboratories and has become an essential tool in routine analysis labs (including environmental and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. Postgraduate students and laboratory staff will find this textbook to be a highly accessible guide to isotope dilution analysis, providing the reader with a sound basis to working with this technique. Experienced researchers will benefit from designing experiments with IDMS methodologies in mind. The authors enjoy a strong reputation in the field of analytical chemistry and the reader will be familiar with their previous research.

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Isotope Dilution Mass Spectrometry (IDMS) is increasingly used in research laboratories and has become an essential tool in routine analysis labs (including environmental and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique.


The first part of this textbook offers a uniform theoretical background, based both on the authors’ experience in organic, speciation and elemental analysis and on the current published literature. In the second part, the comprehensive approach to the many applications of IDMS will ensure this text becomes an essential reference for any analytical laboratory. Emerging fields such as quantitative proteomics and metabolic studies are also discussed. Appendices include example spreadsheets for calculating the isotopic composition of molecules and using the Kragten procedure for determining uncertainties.


Postgraduate students and laboratory staff will find this textbook to be a highly accessible guide to isotope dilution analysis, providing the reader with a sound basis to working with this technique. Experienced researchers will benefit from designing experiments with IDMS methodologies in mind. The authors enjoy a strong reputation in the field of analytical chemistry and the reader will be familiar with their previous research.

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