This is a dual-purpose handbook, extensively illustrated and fully up-to-date with the newest terms, containing a cross-referenced glossary as well as laboratory lists and reference matter dealing with gene technology. The glossary defines in detail some 4,500 terms used across all scientific and medical disciplines working with genes and gene technology. The appendixes include a list of restriction enzymes, SI prefixes, and the Greek alphabet. This is the newest dictionary-handbook of its kind in this fast-moving field, of special value to medical and scientific researchers and advanced students in areas ranging from disease treatment to biodegradable plastics.
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aberrant splicing n. The result of mutations in consensus sequences of introns. Such mutations cause exon skipping, activation of cryptic site, creation of pseudoexon within introns, and intron retention to redefine exon-intron structure, and these result in the direct joining of nonconsecutive exons. In human genome, a single base substitution in the 5 splice site can cause an aberrant splicing event.
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