Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Inhaltsangabe1. Smooth Muscle Myosin: Molecule Conformation, Filament Assembly and Associated Regulatory Enzymes.- 2. Actin and Thin-Filament-Associated Proteins in Smooth Muscle.- 3. Current Concepts on Mechanisms of Force Generation in Airways Smooth Muscle.- 4. Phosphoinositidase C, Inositol Polyphosphates and Force Generation of Airways Smooth Muscle.- 5. The Intracellular Calcium Store in Airways Smooth Muscle.- 6. Current Concepts on Mechanisms of Force Maintenance in Airways Smooth Muscle.- 7. Diglyceride, Protein Kinase C and Force Maintenance of Airways Smooth Muscle.- 8. Sources of Activator Calcium for Force Generation and Maintenance of Airways Smooth Muscle.- 9. G-Proteins in Airways Smooth Muscle.- 10. Cyclic AMP and the Control of Airways Smooth Muscle Tone.- 11. Myosin Dephosphorylation as a Mechanism of Relaxation of Airways Smooth Muscle.- 12. Cyclic GMP and the Control of Airways Smooth Muscle Tone.- 13. Cyclic Nucleotide Phosphodiesterases in Airways Smooth Muscle.- 14. Modulation of Agonist-Stimulated Phosphoinositide Turnover in Airways Smooth Muscle by Cyclic Nucleotide-Dependent and Independent Mechanisms.- 15. Airways Smooth Muscle Cells in Culture. 352 pp. Englisch. Seller Inventory # 9783034876834
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Inhaltsangabe1. Smooth Muscle Myosin: Molecule Conformation, Filament Assembly and Associated Regulatory Enzymes.- 2. Actin and Thin-Filament-Associated Proteins in Smooth Muscle.- 3. Current Concepts on Mechanisms of Force Generation in Airways Smooth Muscle.- 4. Phosphoinositidase C, Inositol Polyphosphates and Force Generation of Airways Smooth Muscle.- 5. The Intracellular Calcium Store in Airways Smooth Muscle.- 6. Current Concepts on Mechanisms of Force Maintenance in Airways Smooth Muscle.- 7. Diglyceride, Protein Kinase C and Force Maintenance of Airways Smooth Muscle.- 8. Sources of Activator Calcium for Force Generation and Maintenance of Airways Smooth Muscle.- 9. G-Proteins in Airways Smooth Muscle.- 10. Cyclic AMP and the Control of Airways Smooth Muscle Tone.- 11. Myosin Dephosphorylation as a Mechanism of Relaxation of Airways Smooth Muscle.- 12. Cyclic GMP and the Control of Airways Smooth Muscle Tone.- 13. Cyclic Nucleotide Phosphodiesterases in Airways Smooth Muscle.- 14. Modulation of Agonist-Stimulated Phosphoinositide Turnover in Airways Smooth Muscle by Cyclic Nucleotide-Dependent and Independent Mechanisms.- 15. Airways Smooth Muscle Cells in Culture. Seller Inventory # 9783034876834
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