Clinical Aspects and Laboratory. Iron Metabolism, Anemias: Novel concepts in the anemias of malignancies and renal and rheumatoid diseases - Softcover

Wick, Manfred; Pinggera, Germar-Michael; Lehmann, Paul

Softcover

ISBN 10: 3211006958 ISBN 13: 9783211006955

Publisher: Springer, 2003

Synopsis

Disturbances of iron metabolism, particularly iron deficiency, are among the most commonly overlooked or misinterpreted diseases. This is due to the fact that the determination of transport iron in serum or plasma, which used to be the test in conventional diagnosis, does not allow a representative estimate of the body’s total iron reserves. A proper estimate was formerly possible only by the costly and invasive determination of storage iron in the bone marrow, however, sensitive, well-standardized immuno-chemical methods for the precise determination of the iron storage protein ferritin in plasma are now available. Since the secretion of this protein correctly reflects the iron stores in the majority of cases, these methods permit fast and reliable diagnosis, particularly of iron deficiency conditions. This book is intended to contribute to a better understanding of the main pathophysiological foundations and diagnostic principles.

About this title

Book Description

5th edition 

From the Back Cover

Iron is essential for most forms of life, including humans. On the other hand, iron is also potentially toxic. Therefore, the control of iron metabolism and maintenance of iron hemostasis is an crucial part of many aspects of human health and disease. Iron deficiency anemia is one of the most common diseases worldwide, but there are also anemias associated with chronic diseases, and other acquired or hereditary defects. Understanding the control of iron metabolism is furthermore important for understanding diseases of iron overload, like hemochromatosis. This booklet is designed for physicians, clinical lab personnel and medical students. It gives an overview about the principles of regulation of iron metabolism and erythropoiesis. In addition, the various disturbances of iron metabolism and the associated clinical findings are described. Special focus lies on the differential diagnosis of the disorders, and the approaches of therapy. Finally, a comprehensive schedule of tests is included available for the determination of iron metabolism-related parameters in serum/plasma and blood, with indication of methodologies applied and reference ranges.

Edition details

• Publisher: Springer
• Publication date: 2003
• Language: English
• ISBN 10: 3211006958
• ISBN 13: 9783211006955
• Binding: Paperback
• Edition number: 5
• Number of pages: 219