The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic (Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products)

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9783211999288: The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic (Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products)

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

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Kinghorn, Douglas A
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Mulzer, Johann H. [Editor]; Kinghorn, A. D. [Series Editor]; Altmann, Karl-Heinz [Contributor]; H?fle, Gerhard [Contributor]; M?ller, Rolf [Contributor]; Prantz, Kathrin [Contributor];
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Johann H. Mulzer (Editor), A. Douglas Kinghorn (Series Editor), Karl-Heinz Altmann (Contributor), Gerhard H?fle (Contributor), Rolf M?ller (Contributor), Kathrin Prantz (Contributor)
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Book Description Springer, 2010. Paperback. Book Condition: New. Softcover reprint of hardcover 1. This item is printed on demand. Bookseller Inventory # DADAX3211999280

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Book Description SPRINGER VERLAG GMBH, Austria, 2010. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis. Softcover reprint of hardcover 1st ed. 2009. Bookseller Inventory # AAV9783211999288

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Book Description Springer. Paperback. Book Condition: New. Paperback. 260 pages. Dimensions: 9.2in. x 6.1in. x 0.6in.Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e. g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783211999288

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