The Nuclear Overhauser Effect in Structural and Conformational Analysis (Methods in Stereochemical Analysis) - Hardcover

D. Neuhaus

Hardcover

ISBN 10: 3527266399 ISBN 13: 9783527266395

Publisher: Wiley-VCH, 1989

Synopsis

This book is a comprehensive treatment of the nuclear Overhauser effect (NOE), an important branch of NMR spectroscopy concerned with structural and conformational problems. It is the only text in this area since 1971. Since that time there have been tremendous changes in the area, particularly with the growth of experiments such as NOE difference spectroscopy, NOESY, the heteronuclear NOE, with applications to an ever-increasing variety of structural and conformational problems in chemistry and biochemistry. The book gives a very clear and integrated account of all these developments. It covers theory, experimental practice, and applications in a unified manner including the influence of exchange and spin-spin-coupling as part of its underlying concepts, and applications to molecules as diverse as cyclobutanes and proteins. The book is of interest primarily to postgraduate organic and inorganic chemists and biochemists who use the NOE in their research, but it is also useful to those who wish to learn the background to the technique, for instance computational chemists , biophysicists, and physical chemists. Although it describes and explains the latest developments, the treatment is suitable for those with only a graduate-level background in chemistry and spectroscopy.

About this title

From the Publisher:

This book is a comprehensive treatment of the nuclear Overhauser effect (NOE), an important branch of NMR spectroscopy concerned with structural and conformational problems. This volume presents the applications to an ever-increasing variety of structural and conformational problems to chemistry and biochemistry. The book gives a very clear and integrated account of all these developments. It covers theory, experimental practice, and applications in a unified manner.

From the Back Cover:

An authoritative review of the state of the art in the Nuclear Overhauser Effect-essential information for organic chemists, biochemists, biophysicists, and NMR spectroscopists

The field of NMR spectroscopy has seen tremendous growth in the last twenty years, particularly advances relating to Nuclear Overhauser Effect (NOE) spectroscopy-the most powerful technique for obtaining structural information on molecules in solution. Extensive and engaging, the Second Edition of the leading reference on the NOE is significantly updated to reflect the latest changes and new approaches in the field.

Neuhaus and Williamson provide an essential guide to the complexities and use of the NOE in a readily accessible, straightforward manner. Their practical handbook features a new chapter addressing the use of NOE data to calculate biomolecular structures. Chapters dealing with the kinetics of the NOE, the effects of exchange and internal motion, and applications of the NOE, are also extensively revised. Cross-referenced in remarkable depth, The Nuclear Overhauser Effect is organized into three main parts:
* Part I describes the theory of the Nuclear Overhauser Effect in a clear, comprehensive fashion
* Part II discusses the considerations involved in implementing NOE experiments, including full coverage of all necessary details for both new and established techniques
* Part III offers examples of how the NOE is used, including applications to defining molecular geometry, stereochemistry, conformation, and biomolecular structure and interactions
The Nuclear Overhauser Effect in Structural and Conformational Analysis, Second Edition, uniquely explains the NOE in detail, making it an indispensable resource for the novice as well as the experienced NMR researcher.

About this edition

• Publisher: Wiley-VCH
• Publication date: 1989
• ISBN 10: 3527266399
• ISBN 13: 9783527266395
• Binding: Hardcover
• Number of pages: 544