Protein Folding Handbook 5-volume set

ISBN 13: 9783527307845

Protein Folding Handbook 5-volume set

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9783527307845: Protein Folding Handbook 5-volume set

How a polypeptide chain folds into a stable and functional protein is probably the most important question in present-day molecular biology. Reliably predicting the folding process allows to deduce protein function from genomic information alone and will bring about a revolution in structural genomics. Understanding the way in which proper protein folding is controlled by the cell is required to find a cure for Alzheimer's and other diseases caused by misfolded proteins.
This unique handbook contains the expertise from more than 60 research groups, covering the entire range of topics in protein folding - from biophysics to molecular medicine.
The first part explains the principles and factors governing protein stability, and how this knowledge may be used to predict folding pathways. It also surveys important techniques used to study the protein folding process, including spectroscopic, chemical and biological techniques.
The second part is devoted to protein folding, unfolding, and misfolding in the cellular context, introducing chaperones and other enzymes involved in protein folding, as well as a study of the pathophysiology of misfolded proteins in amyloid and other disease states. The whole is rounded off by a discussion of the possibility of interfering with the protein folding process by genetic engineering.
The comprehensiveness and outstanding quality of the carefully selected contents make this the ultimate reference for every scientist with an interest in protein folding.

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This unique handbook contains the expertise from more than 60 research groups, covering the entire range of topics in protein folding - from biophysics to molecular medicine. The first part explains the principles and factors governing protein stability, and how this knowledge may be used to predict folding pathways. It also surveys important techniques used to study the protein folding process, including spectroscopic, chemical and biological techniques. The second part is devoted to protein folding, unfolding, and misfolding in the cellular context, introducing chaperones and other enzymes involved in protein folding, as well as a study of the pathophysiology of misfolded proteins in amyloid and other disease states. The whole is rounded off by a discussion of the possibility of interfering with the protein folding process by genetic engineering. The comprehensiveness and outstanding quality of the carefully selected contents make this the ultimate reference for every scientist with an interest in protein folding.

From the Back Cover:

Based on the expertise of more than 60 research groups from around the globe, this unique reference integrates theoretical, biophysical, biochemical and medical aspects of protein folding for an in-depth coverage of the entire field.

Part I
Principles of Protein Stability
Kinetics of Protein Folding
Folding of Membrane Proteins
Structure and Dynamics of Unfolded States
Folding Intermediates
Molecular Dynamics Simulations of Protein Folding

Part II
In vivo Study of Protein Folding
Cellular Function and Regulation of Chaperones
Misfolded Proteins and Prions
Protein Folding Diseases
Design of Stable Proteins
Biotechnology of Protein Folding

Throughout the book, theoretical as well as practical aspects are addressed, including detailed protocols for key techniques in protein folding research.
The comprehensiveness and outstanding quality of the carefully selected contributions render this the ultimate resource for every scientist with an interest in protein folding.

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Book Description 2005. Hardcover. Book Condition: New. 1st. 178mm x 165mm x 248mm. Hardcover. How a polypeptide chain folds into a stable and functional protein is probably the most important question in present-day molecular biology. Reliably predicting the folding pr.Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. 2623 pages. 6.033. Bookseller Inventory # 9783527307845

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Book Description Wiley-VCH Verlag GmbH, Germany, 2005. Hardback. Book Condition: New. 1. Auflage. 255 x 185 mm. Language: English . Brand New Book. This unique handbook contains the expertise from more than 60 research groups, covering the entire range of topics in protein folding - from biophysics to molecular medicine. The first part explains the principles and factors governing protein stability, and how this knowledge may be used to predict folding pathways. It also surveys important techniques used to study the protein folding process, including spectroscopic, chemical and biological techniques. The second part is devoted to protein folding, unfolding, and misfolding in the cellular context, introducing chaperones and other enzymes involved in protein folding, as well as a study of the pathophysiology of misfolded proteins in amyloid and other disease states. The whole is rounded off by a discussion of the possibility of interfering with the protein folding process by genetic engineering. The comprehensiveness and outstanding quality of the carefully selected contents make this the ultimate reference for every scientist with an interest in protein folding. Bookseller Inventory # AAH9783527307845

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