Understanding Carcinogenesis

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9783527314867: Understanding Carcinogenesis
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In this concise, up-to-date guide to the biology of cancer the author manages to present both the basic and the clinical while retaining a simple and concise style. Following an introduction to fundamental concepts related to the clonality of the tumors and the hypermutability of the cancer cells, he continues with a description of genes involved in the process of carcinogenesis and concludes with more complex phenomena of tumor biology, such as the role of the tumor stroma and the metastatic process. A whole section on specific topics includes pharmacogenomics and viral carcinogenesis. In addition, he describes human and animal models of the disease, emphasizing their advantages and their limitations, rounding off with unifying concepts, as well as ongoing and future perspectives. The book makes good use of simple graphs to underline the notions described in the text, a feature that particularly aids comprehension.
With a foreword by Nobel laureate Andrew V. Schally.

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Cancer, the second leading cause of death, is a heterogeneous group of over 100 diseases. It is characterized by disordered and deregulated cellular and stromal proliferation accompanied by reduced cell death. At the molecular level, cancer is a genetic disease that develops due to the accumulation of mutations over time in somatic cells.
This book is a concise, up-to-date introduction to the molecular basis of carcinogenesis. The author manages to present both the basic and the clinical areas while retaining a simple and concise style.
Following an introduction to fundamental concepts related to the clonality of the tumors and the hypermutability of the cancer cells, he continues with a description of genes involved in the process of carcinogenesis and concludes with more complex phenomena of tumor biology, such as the role of the tumor stroma and the metastatic process. A whole section on specific topics includes pharmacogenomics and viral carcinogenesis. In addition, he describes human and animal models of the disease, emphasizing their advantages and their limitations, rounding off with unifying concepts, as well as ongoing and future perspectives. The book makes good use of simple graphs to underline the notions described in the text, a feature that particularly aids comprehension.
With a foreword by Nobel laureate Andrew V. Schally.

About the Author:

Hippokratis Kiaris studied biology at the University of Athens. After graduate studies at the National Hellenic Research Foundation, Athens, and the Medical School, University of Crete, he joined the Molecular Genetics and Oncology Group at the University of Liverpool. From 1998 to 2000 he was appointed research instructor at Tulane University Medical School in the group of Nobel Laureate Andrew Schally. In 2000 he took up a position at the MGH Cancer Center, Harvard Medical School, before returning to the University of Athens in 2002.
His current research focuses on the elucidation of the molecular events that contribute to breast cancer development, and to the mechanistic aspects of tumor-stroma interactions.

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