Antitargets: Prediction and Prevention of Drug Side Effects

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9783527318216: Antitargets: Prediction and Prevention of Drug Side Effects

This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating the current approaches into a single source, and includes several highly instructive case studies that may be used as guidelines on how to improve drug development projects.
With its large section on ADME-related effects, this is key knowledge for every drug developer.

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Addressing a common challenge that is faced by every drug developer, this practice-oriented handbook surveys current knowledge on the occurrence and prevention of adverse drug reactions related to off-target activity of small molecule drugs.
It is unique in collating the current approaches into a single source, and includes several highly instructive case studies that may be used as guidelines on how to improve drug development projects.
Clearly divided into four parts, the first covers general considerations of studying and predicting side effects in drug molecules, while the second part looks at well-known anti-targets that mediate severe side effects. Part three covers the large field of ADME-related effects, focusing on the prevention of cytochrome induction and on drug transporters. The final part presents selected case studies of successful drug development in terms of suppressing unwanted side effects.
The result is key knowledge for medicinal and pharmaceutical chemists, toxicologists, molecular biologists, and pharmaceutists as well as drug developers working in the pharmaceutical industry.

About the Author:

Roy Vaz is the head of investigative pharmacokinetics at the Bridgewater, NJ (USA) location of Sanofi-Aventis Pharmaceuticals. He received his Ph.D. in Organic Chemistry from the University of Florida, Gainesville (USA), after graduating from the Indian Institute of Technology in Mumbai (India). Prior to his present appointment, he has worked with Bristol-Myers-Squibb and Tripos. He is a specialist on the prediction and modeling of cytochrome-mediated drug metabolism.

Thomas Klabunde obtained his PhD in chemistry from the University of M�nster (Germany). After a postdoctoral fellowship at the Texas A&M University, he was appointed Assistant Professor at the Institute for Bioscience and Technology in Houston (USA). Later on, he joined the pharmaceutical research of Sanofi-Aventis in Frankfurt (Germany), where he is currently a group leader. His main interest lies with drug design approaches for G protein-coupled receptors, notably in the areas of lead finding and chemogenomics.

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Roy J. Vaz (editor), Thomas Klabunde (editor), Raimund Mannhold (series editor), Hugo Kubinyi (series editor), Gerd Folkers (series editor)
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Editor: Roy J. Vaz (Sanofi-Aventis, Bridgewater, NJ, USA); Editor: Thomas Klabunde (Sanofi-Aventis, Frankfurt, Germany); Series Editor: Raimund Mannhold (University of Düsseldorf, Germany); Series Editor: Hugo Kubinyi (University of Heidelberg, German
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Book Description Wiley VCH Verlag Gmbh Jan 2008, 2008. Buch. Book Condition: Neu. Neuware - A practice-oriented handbook for drug developers that surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. Includes a large section on ADME-related effects. 480 pp. Englisch. Bookseller Inventory # 9783527318216

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