Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties

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9783527332007: Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research.

The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

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About the Author:

Daniel Erik Otzen is Professor at the Interdisciplinary Nanoscience Centre of the Department of Molecular Biology at Aarhus University, Denmark. A graduate of Aarhus University, he obtained a Ph.D. in protein biophysics from the universities of Aarhus and Cambridge (UK). In 1995, he began work as a research chemist at Novo Nordisk, followed by post-doctoral work at Lund University (Sweden). In 2000, he joined the faculty of Aalborg University before taking up his current appointment at Aarhus in 2007. Professor Otzen has received several awards, including the Prize of the Alzheimer Research Foundation, the Carlsberg Biotechnology Prize and the Silver Medal of the Royal Danish Society. He has published more than 120 research articles and serves as an editor for the journals Biochimica Biophysica Acta and Biophysical Chemistry.

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Book Description Wiley-VCH Verlag GmbH. Hardback. Book Condition: new. BRAND NEW, Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties, Daniel Erik Otzen, Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry. Bookseller Inventory # B9783527332007

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Book Description Book Condition: New. Publisher/Verlag: Wiley-VCH | Molecular and Biological Properties | A modern view of amyloid proteins that focuses on their structural biology and physiological roles in health and disease. This comprehensive handbook is targeted at basic and applied researchers in the biochemical, biomedical and pharmaceutical sectors. | Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research.The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry. | PREFACETHE AMYLOID PHENOMENON AND ITS SIGNIFICANCEIntroductionThe Nature of the Amyloid State of ProteinsThe Structure and Properties of Amyloid SpeciesThe Kinetics and Mechanism of Amyloid FormationThe Link between Amyloid Formation and DiseaseStrategies for Therapeutic InterventionLooking to the FutureSummaryAMYLOID STRUCTURES AT THE ATOMIC LEVEL: INSIGHTS FROM CRYSTALLOGRAPHYAtomic Structures of Segments of Amyloid-Forming ProteinsStability of Amyloid FibersWhich Proteins Enter the Amyloid State?Molecular Basis of Amyloid Polymorphism and Prion StrainsAtomic Structures of Steric Zippers Suggest Models for Amyloid Fibers of Parent ProteinsAtomic Structures of Steric Zippers Offer Approaches for Chemical Interventions against Amyloid FormationSummaryWHAT DOES SOLID-STATE NMR TELL US ABOUT AMYLOID STRUCTURES?IntroductionPrinciples of Solid-State NMR Spectroscopy and Experiments for Structural ConstraintsAmyloid Fibrils Investigated by Solid-State NMR SpectroscopySummaryFROM MOLECULAR TO SUPRAMOLECULAR AMYLOID STRUCTURES: CONTRIBUTIONS FROM FIBER DIFFRACTION AND ELECTRON MICROSCOPYIntroductionHistoryMethodologyRecent Advances in Amyloid Structure DeterminationSummarySTRUCTURES OF AGGREGATING SPECIES BY SMALL-ANGLE X-RAY SCATTERINGIntroductionTheoretical and Experimental AspectsData Analysis and Modeling MethodsStudying Protein Aggregation and Fibrillation Using SAXSGeneral Strategies for Modeling SAXS Data from Protein ComplexesSummary and Final RemarksSTRUCTURAL AND COMPOSITIONAL INFORMATION ABOUT PRE-AMYLOID OLIGOMERSGeneral IntroductionBiophysical Techniques to Study Amyloid OligomersThe Structure and Composition of Amyloid OligomersConcluding RemarksTHE OLIGOMER SPECIES: MECHANISTICS AND BIOCHEMISTRYIntroductionThe Structure - Toxicity Relation of Early AmyloidsThe Oligomer - Membrane ComplexBiochemical Modifications Underlying Amyloid ToxicitySummaryPATHWAYS OF AMYLOID FORMATIONIntroductionNomenclature of the Various Conformational StatesGraphical Representations of the Mechanisms Leading to AmyloidPathways of Amyloid Fibril FormationNucleation Growth versus Nucleated Conformational ConversionSummarySEQUENCE-BASED PREDICTION OF PROTEIN BEHAVIORIntroductionThe Strategy of the Zyggregator PredictionsAggregation Under Other ConditionsPrediction of the Cellular Toxicity of Protein AggregatesRelationship to Other Methods of Predicting Protein Aggregation PropensitiesCompetition between Folding and Aggregation of ProteinsPrediction of Protein Solubility from the Competition between Folding and AggregationSequence-Based Prediction of Protein Interactions with Molecular ChaperonesSummaryTHE KINETICS AND MECHANISMS OF AMYLOID FORMATIONIntroductionClassical Theory of Nucleated PolymerizationThe Theory of Filamentous Growth with Secondary PathwaysSelf-Consistent Solutions for the Complete Reaction Time CourseSummaryFLUORESCENCE SPECTROSCOPY AS A TOOL TO CHARACTERIZE AMYLOID OLIGOMERS AND FIBRILSInt. Bookseller Inventory # K9783527332007

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Book Description Wiley VCH Verlag Gmbh Feb 2013, 2013. Buch. Book Condition: Neu. Neuware - Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry. 481 pp. Englisch. Bookseller Inventory # 9783527332007

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Book Description Wiley VCH Verlag Gmbh Feb 2013, 2013. Buch. Book Condition: Neu. Neuware - Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry. 481 pp. Englisch. Bookseller Inventory # 9783527332007

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Book Description Wiley VCH Verlag Gmbh Feb 2013, 2013. Buch. Book Condition: Neu. Neuware - Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry. 481 pp. Englisch. Bookseller Inventory # 9783527332007

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